Ansari et al. identified a subset of CD4 T cells (CXCR5PD-1) resembling T follicular helper (Tfh) cells in patients with severe dengue. This subset helps B cell responses via IL-21 and can also differentiate into cytotoxic CD4 T cells.
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| http://dx.doi.org/10.1016/j.celrep.2025.115367 | DOI Listing |
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Utilizing Integrated Bioinformatics Analysis to Explore Potential Alterations in Mitochondrial Function Within Immune Cells Associated with Thoracic Aortic Aneurysms.
Bioengineering (Basel)
February 2025
Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Thoracic aortic aneurysm (TAA) is a life-threatening peripheral vascular disease with a complex pathogenesis. Altered mitochondrial function in vascular smooth muscle cells has been implicated in TAA development. However, the link between mitochondrial functional status and immune cell behavior in TAA patients remains largely unexplored.
View Article and Find Full Text PDFCorrelation between immune microenvironment and clinicopathological characteristics and prognosis of primary large B-cell lymphoma of immune-privileged sites.
Pathol Res Pract
December 2024
Department of Pathology, The Tumor Hospital Affiliated to Xinjiang Medical University, No. 789 Suzhou Dongjie, Urumqi, Xinjiang Uygur 830011, PR China. Electronic address:
Objectives: To explore the correlation between tumor-associated macrophages (TAMs), tumor-infiltrating lymphocytes (TILs), and tumor-associated angiogenesis (TAA) in the tumor microenvironment with the clinicopathological characteristics and prognosis of primary large B-cell lymphoma of immune-privileged sites (LBCL-IP).
Methods: A total of 46 cases of LBCL-IP from the Department of Pathology, the Third Affiliated Hospital of Xinjiang Medical University, from January 2010 to February 2024, were collected, along with clinical and follow-up data of LBCL-IP patients. Immunohistochemistry and triple immunofluorescence were used to detect related proteins of TAMs, TILs, and TAA, and to analyze the correlation between TAMs, TILs, TAA, and the polarization of TAMs with the clinical and prognostic factors of LBCL-IP patients.
Nimodipine ameliorates liver fibrosis via reshaping liver immune microenvironment in TAA-induced in mice.
Int Immunopharmacol
September 2024
Department of Emergency Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China. Electronic address:
Nimodipine, a calcium antagonist, exert beneficial neurovascular protective effects in clinic. Recently, Calcium channel blockers (CCBs) was reported to protect against liver fibrosis in mice, while the exact effects of Nimodipine on liver injury and hepatic fibrosis remain unclear. In this study, we assessed the effect of nimodipine in Thioacetamide (TAA)-induced liver fibrosis mouse model.
View Article and Find Full Text PDFPro-inflammatory responses after peptide-based cancer immunotherapy.
Heliyon
June 2024
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Article Synopsis
- Therapeutic vaccinations aim to prevent cancer by triggering immune responses against specific tumor-associated antigens (TAA) found in cancer cells.
- These vaccinations primarily focus on activating CD8 T lymphocytes, which play a crucial role in suppressing tumor growth by releasing cytokines.
- The review discusses how peptide-based vaccines enhance the production of important cytokines like IFN-γ, TNF-α, IL-2, and IL-12, and also examines the mechanisms of T cell activation and dysfunction.
Dendritic cell-derived exosome (DEX) therapy for digestive system cancers: Recent advances and future prospect.
Pathol Res Pract
May 2024
Department of Technical Engineering, Al-Hadi University College, Baghdad 10011, Iraq.
Tumor-mediated immunosuppression is a fundamental obstacle to the development of dendritic cell (DC)-based cancer vaccines, which despite their ability to stimulate host anti-tumor CD8 T cell immunity, have not been able to generate meaningful therapeutic responses. Exosomes are inactive membrane vesicles that are nanoscale in size and are produced by the endocytic pathway. They are essential for intercellular communication.
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