CRISPR screens are widely utilized to identify genes that regulate immune function or mediate sensitivity of cancer cells to immune attack. In this issue of Immunity, Zeng et al. present a computational framework for uncovering gene targets with dual function in both cancer and immune cells and nominate TNFAIP3 as a synergistic target whose ablation strongly elicits an antitumor response.
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| http://dx.doi.org/10.1016/j.immuni.2025.02.016 | DOI Listing |
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Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:
CRISPR screens are widely utilized to identify genes that regulate immune function or mediate sensitivity of cancer cells to immune attack. In this issue of Immunity, Zeng et al. present a computational framework for uncovering gene targets with dual function in both cancer and immune cells and nominate TNFAIP3 as a synergistic target whose ablation strongly elicits an antitumor response.
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