Purpose: The aim of the present study was to explore the impact of different planes of popliteal artery injury (PAI) on the risk of amputation in affected limbs.
Methods: A retrospective analysis was conducted on ninety-four patients who underwent PAI; these patients were divided into an amputation group (n = 26) and a nonamputation group (n = 68) on the basis of whether limb preservation was successful. The data were reconstructed from computed tomography angiography (CTA) of the patients' lower limbs and measured via AW Volume Share 5 software. The height of the popliteal artery injury surface was quantified as follows: "L" was defined as the distance from the origin of the descending genicular artery of the contralateral limb to the origin of the anterior tibial artery; "S" was defined as the distance from the origin of the descending genicular artery of the affected limb to the blood flow interruption site; and "R" was defined as the ratio of S to L (S/L). The risk factors for amputation in patients with PAI were also analysed.
Results: Univariate and multivariate logistic regression analyses revealed that R (odds ratio [OR]=0.876, P = 0.006,95 % CI:0.797-0.963), S (OR=0.792, P = 0.166,95 % CI:0.570-1.102), ischemic time (OR=1.195, P = 0.017,95 % CI:1.032-1.383), and compartment syndrome (OR=5.509, P = 0.055,95 % CI:0.967-31.376) were independent risk factors for amputation in patients with PAI. The receiver operating characteristic (ROC) curve revealed that the AUC values were 0.887 (P < 0.000, 95 % CI: 0.805-0.943) and 0.775 (P < 0.000, 95 % CI: 0.677-0.854) for R and S, respectively. The diagnostic efficiency was highest when the diagnostic threshold values were 0.573 and 11.3 cm, for R and S, respectively. Moreover, the AUC was greater than the AUC (Z = 2.403, P = 0.0162).
Conclusion: The height of the PAI plane is an independent risk factor for amputation in patients with PAI. Greater planes of vascular injury result in greater risk of amputation. R is better than S in the diagnosis of amputation risk in patients with PAI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.injury.2025.112233 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploration of the relationship between the height of the popliteal artery injury plane and the risk of amputation.
Injury
March 2025
The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu 214000, PR China; Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214000, PR China. Electronic address:
Purpose: The aim of the present study was to explore the impact of different planes of popliteal artery injury (PAI) on the risk of amputation in affected limbs.
Methods: A retrospective analysis was conducted on ninety-four patients who underwent PAI; these patients were divided into an amputation group (n = 26) and a nonamputation group (n = 68) on the basis of whether limb preservation was successful. The data were reconstructed from computed tomography angiography (CTA) of the patients' lower limbs and measured via AW Volume Share 5 software.
Is it possible to predict severe postpartum hemorrhage and the need for massive transfusion in placenta previa cases?
Ginekol Pol
March 2025
Department of Obstetrics and Gynecology, Okan University School of Medicine, Istanbul, Türkiye.
Objectives: The aim was to construct a reliable working model for patients with placenta previa (PP) that aids in the prediction of postpartum bleeding potential with data from antenatal imaging studies using both ultrasound (US) and magnetic resonance imaging (MRI).
Material And Methods: Forty-three patients with PP were evaluated initially with the US and then by 3-Tesla MRI. The Placenta Accreata Index (PAI) was used during the US evaluation in order to define the risks.
Novel recurrent mutations and genetic diversity in Sudanese children with Adrenal Insufficiency.
Eur J Endocrinol
March 2025
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Background: Studies of Primary Adrenal Insufficiency (PAI) in African children are rare but in Sudan, congenital adrenal hyperplasia (CAH) and Triple A syndrome are the most common genetic causes. Differential diagnosis is challenging, especially in resource-limited settings, where presentation can mimic common childhood diseases and facilities for biochemical and genetic testing may be restricted.
Patients & Methods: Forty-eight (48) patients from 43 families (31M:17F) with PAI were included (CAH/Triple A excluded).
Molecular Mechanisms of Neutrophil Extracellular Traps in Promoting Gastric Cancer Epithelial-Mesenchymal Transition Through SERPINE-1 Expression.
J Biochem Mol Toxicol
March 2025
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin City, China.
Gastric cancer remains a significant global health concern, with its progression and metastasis often associated with epithelial-mesenchymal transition (EMT). This study investigated the role of neutrophil extracellular traps (NETs) in promoting gastric cancer EMT by regulating SERPINE-1 expression, which encodes plasminogen activator inhibitor-1 (PAI-1). Western blot and immunohistochemistry were used to detect protein expression.
View Article and Find Full Text PDFCustom Peri-Articular Injection Cocktail Preparations are Associated with a Major Financial Burden in Total Joint Arthroplasty.
J Arthroplasty
March 2025
Department of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, 535 East 70(th) Street, New York, NY, 10021, United States of America. Electronic address:
Introduction: Periarticular injections (PAI) are an important component in modern multimodal pain management protocols for total joint arthroplasty. There is a wide variety of formulas reported in the literature, from simple bupivacaine to surgeon-specific "cocktails" that include up to seven different components. Due to the broad lack of standardization in PAI formulations, this study aimed to evaluate the cost savings associated with our institution's transition to a standardized approach while ensuring no adverse impact on inpatient pain outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!