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DiffErential attainment and Factors AssoCiated with Training applications and Outcomes (DE FACTO) study: plastic surgery in the United Kingdom.
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Department of Trauma and Orthopaedics, Barts Health NHS Trust, London, UK.
Predictive framework to evaluate ternary nanocomposite over surface subjected to novel physical perspective.
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Department of Mathematics, AIR University, Sector E-9, Islamabad, Pakistan.
Fluids possessing advanced thermal capabilities are a requirement of today's world scientific technology and are an inherent vital part of diversified large-scale processes. As a result, the induction of nanometric-sized particles has been considered an emerging approach to achieve advanced liquids. Various combinations have been used to enhance the efficiency of nanofluids in thermal engineering systems.
View Article and Find Full Text PDFDiversity of ER-positive and HER2-negative breast cancer stem cells attained using selective culture techniques.
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Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Breast cancer stem cells are a promising therapeutic target in cancer. We explored breast cancer stem cell diversity and establish a methodology for selectively culturing breast cancer stem cells. We collected breast cancer tissues from surgical samples of treatment-naïve patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.
View Article and Find Full Text PDFComparison of the multivariate genetic architecture of eight major psychiatric disorders across sex.
Nat Genet
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Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Differences in the patterning of genetic sharing between groups of individuals may arise from biological pathways, social mechanisms, phenotyping and ascertainment. We expand genomic structural equation modeling to allow for testing genomic structural invariance (GSI), that is, the formal comparison of multivariate genetic architecture across groups. We apply GSI to compare the autosomal multivariate genetic architecture of eight psychiatric disorders spanning three factors (psychotic, neurodevelopmental and internalizing) between cisgender males and females.
View Article and Find Full Text PDFiSoMAs: Finding isoform expression and somatic mutation associations in human cancers.
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Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Aberrant alternative splicing, prevalent in cancer, impacts various cancer hallmarks involving proliferation, angiogenesis, and invasion. Splicing disruption often results from somatic point mutations rewiring functional pathways to support cancer cell survival. We introduce iSoMAs (iSoform expression and somatic Mutation Association), an efficient computational pipeline leveraging principal component analysis technique, to explore how somatic mutations influence transcriptome-wide gene expression at the isoform level.
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