Background: Child maltreatment is a public health concern associated with increased youth internalizing symptoms. School connectedness has been shown to play a protective role in the relationship between child maltreatment and externalizing symptoms; yet, its protective role on internalizing symptoms for youth in different racial/ethnic subgroups remains underexplored.
Objective: This study aimed to examine whether school connectedness buffers the effect of child maltreatment on internalizing symptoms for White, Black, Latino/Hispanic, and multiracial youth.
Participants And Setting: Data were drawn from the Future of Families and Child Wellbeing Study, a longitudinal birth cohort study in 20 US cities, comprising 3021 youth with maltreatment experiences.
Methods: Ordinary least squares regression models were conducted separately for racial/ethnic subgroups to examine the interaction effect between child maltreatment subtypes and school connectedness on internalizing symptoms (i.e., youth-reported depression/anxiety, caregiver-reported internalizing symptoms) for White, Black, Latino/Hispanic, and multiracial youth.
Results: School connectedness was generally associated with lower levels of youth internalizing symptoms for all racial/ethnic groups. Interaction effects suggested that, for White youth only, school connectedness moderated the relationship between psychological aggression and caregiver-reported youth internalizing symptoms (B = -1.46, p = .029) and physical assault and youth-reported depressive symptoms (B = -1.04, p = .044).
Conclusions: While school connectedness was linked to lower internalizing symptoms for all youth, its buffering effects against child maltreatment were less evident among minoritized racial/ethnic groups. Continued efforts should prioritize creating supportive school contexts to better serve the needs of racially/ethnically minoritized youth with maltreatment histories.
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http://dx.doi.org/10.1016/j.chiabu.2025.107399 | DOI Listing |
Child Abuse Negl
March 2025
School of Social Work, University of Michigan, Ann Arbor, MI, USA.
Background: Child maltreatment is a public health concern associated with increased youth internalizing symptoms. School connectedness has been shown to play a protective role in the relationship between child maltreatment and externalizing symptoms; yet, its protective role on internalizing symptoms for youth in different racial/ethnic subgroups remains underexplored.
Objective: This study aimed to examine whether school connectedness buffers the effect of child maltreatment on internalizing symptoms for White, Black, Latino/Hispanic, and multiracial youth.
ACS Chem Neurosci
March 2025
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Bispecific antibodies (bAbs) that engage cerebrovascular targets, induce transport across the blood-brain barrier (BBB), and redistribute to secondary targets within the brain parenchyma have the potential to transform the diagnosis and treatment of a wide range of central nervous system disorders. Full understanding of the pharmacokinetics (PK) of these agents, including their potential for delivering cargo into brain parenchymal cells, is a key priority for the development of numerous potential therapeutic applications. To date, the brain PK of bAbs that target transferrin receptor (TfR-1) and CD98 heavy chain (CD98hc) has been characterized using techniques incapable of distinguishing between CNS clearance of intact protein from uptake and catabolism by brain parenchymal cells.
View Article and Find Full Text PDFFront Psychiatry
February 2025
Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Background: FOXP1 syndrome is a genetic neurodevelopmental disorder associated with complex clinical presentations including global developmental delay, mild to profound intellectual disability, speech and language impairment, autism traits, attention-deficit/hyperactivity disorder (ADHD), and a range of behavioral challenges. To date, much of the literature focuses on childhood symptoms and little is known about the FOXP1 syndrome phenotype in adolescence or adulthood.
Methods: A series of caregiver interviews and standardized questionnaires assessed psychiatric and behavioral features of 20 adolescents and adults with FOXP1 syndrome.
Psychol Assess
March 2025
Institute of Child Development, College of Education and Human Development, University of Minnesota.
Research suggests there are differences in children's internalizing and externalizing symptoms as a function of age, race, sex, and socioeconomic status (SES). Males, Black children, and children experiencing lower SES have been rated as having more externalizing problems. Female and older children have been rated as having higher internalizing symptoms.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
March 2025
Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.
During the COVID-19 pandemic, some children experienced psychological distress. Moreover, pandemic-related stressors were associated with changes in hair cortisol concentrations (HCC) in youth. Research has shown that parental distress influenced children's well-being during the pandemic, but it remains unclear whether parental distress is associated with children's HCC during the pandemic.
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