It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the Tc-MAG3, Tc-DTPA, and Tc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old. The results showed that the highest absorbed dose was by kidneys and when Tc-DMSA was used. Also, the highest and lowest absorbed dose in the organs occurred when Tc-DMSA and Tc-MAG3 were used, respectively. The simulation results were in good agreement with the ICRP 128 data.
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http://dx.doi.org/10.1016/j.apradiso.2025.111772 | DOI Listing |
J Genet Eng Biotechnol
March 2025
Karpagam College of Pharmacy, Coimbatore 641 032 Tamil Nadu, India; The Tamil Nadu Dr. M.G.R. Medical University, Chennai 600032 Tamil Nadu, India. Electronic address:
Introduction: Improving the pharmacokinetics of drugs is achieved through nano formulations and the role of natural product in the synthesis of nanomaterials is gaining prominence due to its eco-friendly nature, cost-effectiveness, and demonstrated efficacy. Metal nanoparticles (NPs) derived from Ipomoea aquatica Forsskal have been synthesized and evaluated for their antioxidant and antidiabetic properties towards enhancing the anticancer activity of the plant extracts.
Methodology: Hydroalcoholic extract was obtained from the entire Ipomoea aquatica plant and utilized as a key ingredient in the green synthesis of metal NPs.
Radiat Res
March 2025
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
While biological studies of the FLASH effect in proton beams have mainly been performed in the plateau region at maximum beam energy and current, this type of delivery has limited clinical applications. Naturally, it is anticipated that plans to treat patients clinically with FLASH-radiotherapy (FLASH-RT) will capitalize on the Bragg peak. However, as the proton spot widens with depth, the time required to deliver the entire dose to any single point increases.
View Article and Find Full Text PDFAppl Radiat Isot
March 2025
Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging, Geneva University Hospital, CH-1211, Geneva, 4, Switzerland.
It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the Tc-MAG3, Tc-DTPA, and Tc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old.
View Article and Find Full Text PDFSci Rep
March 2025
Radiation Applications Research School, Nuclear Science and Technology Research Institute, AEOI, PO Box 11365-3486, Tehran, Iran.
This paper presents a novel digital instrument designed for measuring radiation doses in Ethanol-Chlorobenzene (ECB) dosimeters, based on oscillometry method. ECB dosimeters are versatile tools for radiation measurement, particularly in medical and industrial applications. Various components of the device including measuring cell, analog and digital circuits were designed, simulated, optimized and verified.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
March 2025
Department of Physics, The University of Adelaide, Adelaide SA 5005, Australia; Allied Health & Human Performance, University of South Australia, Adelaide SA 5001, Australia.
Purpose: [Ac]Ac-DOTATATE is a promising treatment option for patients with neuroendocrine tumors. A concern with Ac is that the decay energy can break the bond to the targeting vehicle, producing free daughter radionuclides in the body. Daughter migration is generally not considered in clinical dosimetry, and therefore its effect needs to be studied.
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