This study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure. XRD analysis showed a graphite-like crystalline structure, while FTIR and XPS studies confirmed the presence of OH, CC, and CO functional groups on the surface. The biological activity of CQDs demonstrated selective cytotoxicity, inducing significant cell death in cancer cells while exhibiting low toxicity in healthy cells. More pronounced morphological changes were observed in HEp-2 and SaOS-2 cells, while HEK-293 cells showed negligible changes. These findings suggest that quantum dots could serve as a potential alternative for cancer treatment.
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http://dx.doi.org/10.1016/j.bioorg.2025.108340 | DOI Listing |
Anal Chim Acta
May 2025
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, 510006, PR China.
Background: Creatinine is a small molecule disease biomarker that reflects kidney function, accurate and effective detection of creatinine will play an important role in the prevention and treatment of diseases. Currently, commonly used creatinine detection methods are limited by expensive instruments, complex sample preparation, many interference factors from biological samples, and environmental factors that can affect the accuracy of the measurement. Therefore, developing a fast, simple, inexpensive, sensitive analysis method that can eliminate background interference and provide multi-detection modes has strong attraction and value.
View Article and Find Full Text PDFBiosens Bioelectron
March 2025
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. Electronic address:
The diagnosis of apoptosis is of particular importance for assessing apoptosis-related disease progression and improving the therapy efficiency. Caspase-3 is the most frequently activated cysteine protease and a key mediator of cell apoptosis, therefore, its activity assay is vital. Here, by encapsulating of MAPbI in NH-MIL-125(Ti) and constructing "Z-scheme" structure between CdInS microspheres and CdS quantum dots (QDs) to obtain high-photoelectrochemical (PEC)-stability and large-photocurrent NH-MIL-125(Ti)@MAPbI/Au NPs photocathode and CdInS/CdS QDs photoanode, respectively, a new dual-photoelectrode self-powered PEC platform was constructed for highly sensitive and blocker-free assay of caspase-3 activity.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Department of Chemistry, Faculty of Science and Technology, Thammasat University, Pathumthani 12120, Thailand; Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
A novel fluorescence sensor utilizing label-free nitrogen self-doped carbon dots (NCDs) was developed for the sensitive, selective, and rapid determination of dichloran fungicide, popularly used in agricultural and horticultural fields. The NCDs were prepared from maleic anhydride and diethylenetriamine via a one-step pyrolysis process. They demonstrated strong blue fluorescence emission with a quantum yield of 12 %.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Addiction and Neuroscience Research Unit, Health Science Campus, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia. Electronic address:
In this study, a novel analytical method was developed for the determination of bupropion in pharmaceutical formulations and spiked plasma samples using N, S co-doped carbon quantum dots (N,S CQDs) as a fluorescent probe. The N,S CQDs were thoroughly characterized and its optical properties were investigated. The developed N,S CQDs exhibited blue emission at 435 nm upon excitation at 357 nm.
View Article and Find Full Text PDFThis study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure.
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