Soil arsenic (As) contamination poses a significant threat to food security and human health. Diatomaceous earth (DE) as a representative exogenous mineral silicon can effectively regulate the migration and transformation of As in the soil-rice system. However, the mechanisms underlying the effects of DE application on As uptake, translocation, and stress regulation in rice remain unclear. In this study, pot experiments were conducted to investigate the effects of applying different amounts of DE on As uptake, translocation, and key physiological and biochemical indicators in rice. The results demonstrated that the application of DE significantly inhibited As uptake and translocation in rice, and reduced As content in brown rice by 40.96-85.88 %. The application of DE promoted As adsorption by iron plaque formation on rice root surface, increased the capacity of cell wall for As immobilization, and promoted greater As accumulation in husk by regulating the expression of transporter genes, thereby reducing As content in brown rice. The application of DE regulated antioxidant enzyme activities, and alleviated the toxic effects of As in rice. This study has deepened our understanding of the mechanisms by which DE inhibits As uptake and translocation in rice, and provided more biological knowledge for reducing arsenic accumulation and mitigating As stress in rice.
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http://dx.doi.org/10.1016/j.jhazmat.2025.137884 | DOI Listing |
Plant Physiol Biochem
February 2025
Division of Basic Sciences, Indian Institute of Horticultural Research, Bengaluru, Karnataka, 560089, India. Electronic address:
Salinity stress poses a significant threat to crop production due to rapid soil salinization as a consequence of climate change. Brinjal, a vital and resilient vegetable crop with extensive genetic variation, exhibits a diverse range of salt tolerance responses. Salt-tolerant and susceptible brinjal genotypes were assessed for their differential tolerance mechanisms under 8 dS m salinity.
View Article and Find Full Text PDFJ Hazard Mater
March 2025
College of Life and Environmental Sciences, Central South University of Forestry and Technology, Changsha, Hunan 410004, China; Hunan Provincial Key Laboratory of Wetland and Soil Ecological Remediation, Hunan, China; Yuelushan Laboratory, Hunan, China.
Soil arsenic (As) contamination poses a significant threat to food security and human health. Diatomaceous earth (DE) as a representative exogenous mineral silicon can effectively regulate the migration and transformation of As in the soil-rice system. However, the mechanisms underlying the effects of DE application on As uptake, translocation, and stress regulation in rice remain unclear.
View Article and Find Full Text PDFACS Chem Neurosci
March 2025
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Bispecific antibodies (bAbs) that engage cerebrovascular targets, induce transport across the blood-brain barrier (BBB), and redistribute to secondary targets within the brain parenchyma have the potential to transform the diagnosis and treatment of a wide range of central nervous system disorders. Full understanding of the pharmacokinetics (PK) of these agents, including their potential for delivering cargo into brain parenchymal cells, is a key priority for the development of numerous potential therapeutic applications. To date, the brain PK of bAbs that target transferrin receptor (TfR-1) and CD98 heavy chain (CD98hc) has been characterized using techniques incapable of distinguishing between CNS clearance of intact protein from uptake and catabolism by brain parenchymal cells.
View Article and Find Full Text PDFCirculation
March 2025
Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St. Luc and Université catholique de Louvain, Brussels, Belgium (L.Y.M.M., H.E., D.d.M., R.V., N.F., J.-L.B.).
Background: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.
View Article and Find Full Text PDFPlant Cell Environ
March 2025
Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, China.
Plant growth-promoting rhizobacteria (PGPR) are widely recognized for enhancing the absorption of mineral nutrients by crops. While Sphingobium species have been reported as PGPRs, their capacity to improve nitrogen use efficiency (NUE) and the underlying regulatory mechanisms are not yet fully understood. Here, a strain 41R9, isolated from the rhizosphere of N-deficient rapeseed, was found to significantly enhance the growth performance of rapeseed under both low and normal N conditions.
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