Purpose: Medically tailored transitional foods (TFs) may be a clinically viable alternative to pureed consistency for individuals requiring texture-modified foods. However, little remains known about the performance of TFs during the swallow. The purpose of this investigation was to describe oropharyngeal swallowing physiology in patients with dysphagia during consumption of TFs as compared to pureed solids.
Method: Retrospective chart reviews were conducted on 31 long-term acute care hospital inpatients (23 males; = 57.5 years), who all had a primary medical diagnosis of acute respiratory failure. All patients received a videofluoroscopic swallow study that included both pureed and transitional solid (Savorease Therapeutic Foods) trials. Swallow function was assessed and described following the Modified Barium Swallow Impairment Profile (MBSImP) interpretation approach.
Results: No statistically significant differences in scores were observed between pureed and transitional solids for any of the MBSImP component scores. Similarly, no statistically significant differences were observed in overall oral or pharyngeal composite scores. Although a majority of the individual patients performed similarly on both consistencies across the components scores, there was some variability across a few scores, with a subset of patients performing better with transitional solids for oral and pharyngeal residue and a subset of patients performing better with pureed solids for bolus preparation and initiation of the pharyngeal swallow. No instances of airway invasion were present across any of the solids trialed.
Conclusions: The findings of this pilot study revealed that high-dissolving transitional solids did not increase apparent risk as compared to pureed textures, as there were no significant differences in swallowing safety and only some differences were observed in performance between the two textures. These findings may support the use of transitional solids as a "bridge" and safe consistency to facilitate progression to higher, more challenging textures in medically complex persons with dysphagia based on individual performance. This work represents an important initial step toward the integration of transitional solids into evaluation protocols, texture recommendations, and, potentially, into treatment.
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http://dx.doi.org/10.1044/2025_AJSLP-24-00099 | DOI Listing |
Am J Speech Lang Pathol
March 2025
Communication Disorders and Sciences, University of Oregon, Eugene.
Purpose: Medically tailored transitional foods (TFs) may be a clinically viable alternative to pureed consistency for individuals requiring texture-modified foods. However, little remains known about the performance of TFs during the swallow. The purpose of this investigation was to describe oropharyngeal swallowing physiology in patients with dysphagia during consumption of TFs as compared to pureed solids.
View Article and Find Full Text PDFJ Am Chem Soc
March 2025
Institute for Decarbonization Materials, University of California, Berkeley, California 94720, United States.
The efficient removal of CO from exhaust streams and even directly from air is necessary to forestall climate change, lending urgency to the search for new materials that can rapidly capture CO at high capacity. The recent discovery that diamine-appended metal-organic frameworks can exhibit cooperative CO uptake via the formation of ammonium carbamate chains begs the question of whether simple organic polyamine molecules could be designed to achieve a similar switch-like behavior with even higher separation capacities. Here, we present a solid molecular triamine, 1,3,5-tris(aminomethyl)benzene (TriH), that rapidly captures large quantities of CO upon exposure to humid air to form the porous, crystalline, ammonium carbamate network solid TriH(CO)·HO (TriHCO).
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
University of Eastern Finland, Deaprtment of Chemistry, Yliopistokatu 7, 80101, Joensuu, FINLAND.
We studied a family of coordination compounds with short intramolecular spatial separation between an organic chromophore and a metal centre. The specific geometry was realized by means of anthracene-functionalized tertiary aryl phosphanes. Their silver and gold complexes (1, 2) operate as conventional fluorophores, with photophysical behavior defined by anthracene-localized allowed transitions.
View Article and Find Full Text PDFSci Adv
March 2025
Department of Electrical and Photonics Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
We propose a mechanism for generating single photons in the mid-infrared (MIR) using a solid-state or molecular quantum emitter. The scheme uses cavity quantum electrodynamics (QED) effects to selectively enhance a Frank-Condon transition, deterministically preparing a single Fock state of a polar phonon mode. By coupling the phonon mode to an antenna, the resulting excitation is then radiated to the far field as a single photon with a frequency matching the phonon mode.
View Article and Find Full Text PDFMol Pharm
March 2025
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Polyamorphism in organic molecules is a poorly understood and controversial phenomenon related to amorphous materials. Although very few studies, including our own, have demonstrated the existence of polyamorphism in drug molecules, this solid-state phenomenon is still very elusive and the investigation of its occurrence in other drugs is fundamental to understand its formation. Indomethacin (IND) has been recently discussed in the literature as a potential drug exhibiting polyamorphism.
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