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Depolarization Through Public-Sector Leadership Development: Emerging Leaders and Fellows Programs, United States, 2015‒2024.
Am J Public Health
April 2025
Morgan McDonald is the National Director for Population Health and Health Equity Leadership at the Milbank Memorial Fund, New York, NY.
Directing depolarization efforts toward those with authority over public health funding and population health policies has great potential to improve health outcomes. Two nonpartisan legislative and executive branch state leadership programs demonstrated personal growth and mutual respect among participants necessary for depolarization that was evidenced by cross-state and cross-party policy implementation. Intentional cohort selection of politically and demographically diverse participants, ground rules based on fundamental values, and curriculum emphasizing collective problem-solving built trust and curiosity despite differing viewpoints.
View Article and Find Full Text PDFDepolarizing Health Policy Through Intergenerational Conversations.
Am J Public Health
April 2025
Bhav Jain is with the Stanford University School of Medicine, Stanford, CA. John C. Lin is with the Perelman School of Medicine, University of Pennsylvania, Philadelphia. Jerome M. Adams is with the Center for Community Health Enhancement and Learning, Purdue University, West Lafayette, IN.
Induction of mitochondrial damage via the CREB3L1/miR-34c/COX1 axis by porcine epidemic diarrhea virus infection facilitates pathogenicity.
J Virol
March 2025
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Porcine epidemic diarrhea virus (PEDV) is a primary cause of viral diarrhea in neonatal piglets, leading to substantial economic losses in the swine industry globally. It primarily targets epithelial cells of the small intestine, compromising intestinal function and resulting in the death of affected animals. As mitochondria are essential for maintaining gut health, this study investigates the effects of PEDV infection on mitochondrial function in small intestinal epithelial cells and its subsequent impacts.
View Article and Find Full Text PDFDual action of sphingosine 1-phosphate pathway in in vitro models of global cerebral ischemia.
Neurobiol Dis
March 2025
Dept. of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:
It is well accepted that sphingolipids play an important role in the pathological process of cerebral ischemia. In the present study we have investigated the involvement of sphingosine 1-phosphate (S1P) pathway in two different in vitro models of global ischemia. In organotypic hippocampal slices exposed to oxygen and glucose deprivation (OGD) we evaluated the mRNA expression of S1P metabolic enzymes and receptors (S1P) by Real Time-PCR.
View Article and Find Full Text PDFA positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy.
Cell Discov
March 2025
Faculty of Healthy Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macau, China.
PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly focused on its post-translational modifications, while the transcriptional regulation of PINK1 is much less understood. Herein, we reported a novel mechanism in control of PINK1 transcription by SMAD Family Member 3 (SMAD3), an essential component of the transforming growth factor beta (TGFβ)-SMAD signaling pathway.
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