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The Evolving Overdose Crisis: United States Needs Robust Policy Change to Address the Fourth Wave.
Am J Public Health
April 2025
Shoshana V. Aronowitz is with the Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, PA. Megan K. Reed is with the Department of Emergency Medicine and the Center for Connected Care at Sidney Kimmel Medical College, and the College of Population Health, Thomas Jefferson University, Philadelphia.
The UHPLC-MS/MS method for the determination of 26 synthetic benzimidazole opioids (nitazene analogs) with isomers separation.
J Pharm Biomed Anal
March 2025
Wroclaw University of Science and Technology, Faculty of Medicine, Department of Social Sciences and Infectious Diseases, 27 Wybrzeże Wyspiańskiego, Wrocław 50370, Poland.
The global opioid crisis is a public health emergency characterized by the widespread misuse of opioid drugs, leading to high rates of addiction, overdose, and death. Initially driven by the over-prescription of opioid painkillers, it has evolved into a worldwide epidemic exacerbated by the rise of potent synthetic opioids. Benzimidazole opioids ('nitazenes') are one group within this class of compounds that have garnered increasing attention in recent years due to their addictive potential and growing presence in illicit drug markets.
View Article and Find Full Text PDFPerceived impacts of North Americas first de-medicalized safer supply program.
Subst Abuse Treat Prev Policy
March 2025
Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
Background: The Drug User Liberation Front led an evaluation of a non-medicalized model of safer supply known as a "Compassion Club." This club sourced, rigorously tested, packaged, and accurately labeled certain illicit substances and then provided them to club members at cost in order to investigate the effects and feasibility of a non-medical model of safer supply. Operating for 14 months, the club provided low-cost, quality-controlled illicit substances to individuals at risk of fatal overdose in Vancouver, Canada's Downtown Eastside neighbourhood.
View Article and Find Full Text PDFProduct and trial design considerations on the path towards a vaccine to combat opioid overdose.
NPJ Vaccines
February 2025
Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.
View Article and Find Full Text PDFComparison of heroin and fentanyl use in US nationally representative surveys.
Addict Sci Clin Pract
February 2025
Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Background: Given the opioid overdose crisis, surveillance of evolving opioid use patterns is critical to the effective deployment of mitigation strategies. The National Survey on Drug Use and Health (NSDUH) provided the first annual US estimate of illicitly manufactured fentanyl (IMF) use in 2022. However, as a household survey, NSDUH may not capture the full extent of population heroin and IMF use.
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