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Altered Bile Acids and Pouch Microbiota Composition in Patients With Chronic Pouchitis.
Inflamm Bowel Dis
March 2025
Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Introduction: The intestinal dysfunction plays an important role in the decreased growth performance of broiler chickens under high stocking density. Gut microbiota plays an important role in maintaining intestinal health. However, the modulation pathway of gut microbiota by regulating the intestinal barrier and histomorphology remains unknown.
View Article and Find Full Text PDFBacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review).
Oncol Lett
April 2025
Department of Thyroid and Breast Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China.
Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood and require further investigation. In the present study, the current literature was reviewed to evaluate the roles of microbial metabolites in the development of BC and its response to treatment.
View Article and Find Full Text PDFAltered KEGG pathways are associated with different immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men.
BMC Infect Dis
March 2025
School of Public Health, Fudan University, Shanghai, China.
Background: The association between Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways and immunologic non-response among people living with HIV (PLHIV) on antiretroviral therapy (ART) is not well documented. This study aimed to characterize KEGG metabolic pathways among HIV-infected men who have sex with men (MSM) with different immunologic responses.
Methods: We recruited HIV-uninfected MSM (healthy controls, HC) and HIV-infected MSM on ART > 24 months in Guangzhou, June-October 2021.
Preventive effect of quinoa polysaccharides on lipopolysaccharide-induced inflammation in mice through gut microbiota regulation.
Int J Biol Macromol
March 2025
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China. Electronic address:
Inflammation significantly influences the development of gastrointestinal (GI) diseases such as inflammatory bowel diseases (IBD)and ulcerative colitis, which disrupts normal digestive functions, leading to tissue damage and various symptoms. This research explores the preventive effects of quinoa polysaccharides (QPS) on lipopolysaccharide (LPS)-induced systemic acute inflammation in mice and their mechanism of action. The findings revealed that QPS alleviated LPS-induced inflammation symptoms, enhanced the mice behavior score and their immune organ index, reduced pro-inflammatory cytokines (IL-6, TNF-α and IL-1β) levels, elevated the expression level of tight junction proteins (ZO-1, MUC2).
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