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Mirror Therapy in Unilateral Amputee Patients With Phantom Limb Pain.
Pain Manag Nurs
March 2025
Department of Angiology and Vascular Surgery Department, Clínic Barcelona, Barcelona, Spain. Electronic address:
Unlabelled: Up to 90% of amputee patients have phantom limb pain (PLP), which is difficult to treat. The aim of this study was to assess the medium and long-term efficacy of mirror therapy (MT) in unilateral amputee adults with PLP.
Methods: We carried out an uncontrolled prospective longitudinal study.
Single-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFHistological Assessment of the Anti-Inflammatory Effectiveness of Peperomia pellucida Extract Administered to the Gingival Sulcus in Rats Induced with Periodontitis.
Eur J Dent
March 2025
Departement of Oral Biology, Faculty of Dentistry, Jenderal Achmad Yani University, Jawa Barat, Indonesia.
This study aims to assess the impact of extract on periodontitis in rats, using the Papillary Bleeding Index (PBI), gingival index (GI), and histological evaluation of key inflammatory cells such as osteoclasts, osteoblasts, polymorphonuclear neutrophils (PMNs), macrophages, and fibroblasts to explore its potential in reducing inflammation and preserving periodontal tissue.The extract was prepared using the reflux method with 96% ethanol as a solvent, followed by phytochemical screening and antibacterial testing via the disk diffusion method. This study utilized a posttest control group experiment with 24 Wistar rats, divided into four groups: nonperiodontitis, no-treatment, chlorhexidine-treated (CHX), and extract-treated groups, with the latter three groups induced with periodontitis.
View Article and Find Full Text PDF20-Week Toxicity Study of Rotigotine Behenate Extended-Release Microspheres for Intramuscular Injection in Sprague Dawley Rats.
Food Chem Toxicol
March 2025
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong 264003, China. Electronic address:
Based on the concept of continuous dopaminergic stimulation (CDS), Rotigotine Behenate extended-release microspheres for injection (RBEM) are currently under development. To support human clinical trials of RBEM, a 20-week repeat-dose toxicity study was conducted. SD rats intramuscularly received RBEM (60, 180, and 540 mg/kg) once every 4 weeks for 5 repeated doses followed by a 12-week recovery period, no clear sex difference was noted in the plasma exposure of rotigotine in rats, and the exposure generally increased in a dose-proportional manner.
View Article and Find Full Text PDFImpact of one week of Ayurveda-based therapy, lifestyle and diet modification in heart failure patients with reduced ejection fraction: A retrospective study.
J Ayurveda Integr Med
March 2025
Physiotherapy Department, Madhavbaug Khopoli Cardiac Hospital, Thane, Maharashtra, India.
Background: Management of Chronic Heart Failure (CHF) is quite challenging, and its prognosis remains poor. Thus, alternative and conventional treatment approaches with lifestyle modifications are needed to enhance the quality of life. One such approach is heart failure reversal treatment (HFRT) that includes Snehana (massage), Swedana (fomentation therapy), Basti (per rectal drug administration), and Hridaydhara.
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