As shale gas is an unconventional energy source, it is believed to be essential for achieving green resource development and improving the energy supply-demand balance. However, owing to shale's substantial anisotropic properties and various microstructures, its gas flow characteristics and transport mechanisms are exceedingly complex. Therefore, accurately predicting gas permeability evolution in shale pores was considered to be important for energy development. In this study, an examination of the apparent volumetric strain, caused by the synergistic effects of effective stress and gas adsorption, combined with analysis of dynamic changes in pores in different directions has been undertaken. Based on the Knudsen number (), gas flow mechanisms in shale were separated further to create an anisotropic apparent permeability model. The model was validated by publicly available experimental data concerning the permeability under different stress conditions. The influence of different flow regimes and mechanisms on permeability changes during shale reservoir development has been discussed and analyzed with a model parameter sensitivity analysis being carried out. The results demonstrated that if both mechanisms (effective stress and gas adsorption) were ignored, the shale permeability would be underestimated; however, if shale's anisotropic mechanical properties were ignored, the apparent permeability would be overestimated. Our findings could provide theoretical guidance for energy exploitation, which would be beneficial in contributing to sustained and rapid energy development.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.langmuir.4c04616 | DOI Listing |
Langmuir
March 2025
College of Mining, Guizhou University, Guiyang 550025, PR China.
As shale gas is an unconventional energy source, it is believed to be essential for achieving green resource development and improving the energy supply-demand balance. However, owing to shale's substantial anisotropic properties and various microstructures, its gas flow characteristics and transport mechanisms are exceedingly complex. Therefore, accurately predicting gas permeability evolution in shale pores was considered to be important for energy development.
View Article and Find Full Text PDFNMR Biomed
April 2025
Neurological Disorders and Imaging Section, Neuroscience and Cell Biology Research Institute, School of Health and Medical Sciences, City St George's, University of London, London, UK.
We demonstrate that quasi-diffusion imaging (QDI) is a signal representation that extends towards the negative power law regime. We evaluate QDI for in vivo human and ex vivo fixed rat brain tissue across -value ranges from 0 to 25,000 s mm, determine whether accurate parameter estimates can be acquired from clinically feasible scan times and investigate their diffusion time-dependence. Several mathematical properties of the QDI representation are presented.
View Article and Find Full Text PDFInt J Pharm
February 2025
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA. Electronic address:
Passive permeability through biological membranes requires partitioning of drug molecules into the lipid bilayer and subsequent permeation. Most drugs are weak acids or bases, making their ionization constants (pK) critical for predicting permeation across biological barriers. The pH-partition hypothesis posits that only the uncharged form contributes to passive permeability, suggesting a proportional relationship between permeability and uncharged fraction.
View Article and Find Full Text PDFAAPS PharmSciTech
February 2025
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230038, Anhui, China.
Due to the poor solubility, permeability, stability and tumor-targeting ability of norcantharidin (NCTD), currently commercially available NCTD formulations require patients to take the medicine more frequently. Moreover, the formulation of NCTD themselves have certain toxicity, thus showing unsatisfactory therapeutic outcomes and serious systemic side effects. Based on the specific acidic environment at the tumor site, in this study, the pH-sensitive NCTD solid self-microemulsion (NCTD@CS-DMMA SSME) was prepared by introducing 2,3-dimethylmaleic acid amide modified chitosan (CS-DMMA), and it was wrapped in colon-coated capsule to achieve stable and controlled drug release in the acidic environment of colonic tumors.
View Article and Find Full Text PDFMol Pharm
March 2025
Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic.
Permeability is an important molecular property in drug discovery, as it co-determines pharmacokinetics whenever a drug crosses the phospholipid bilayer, e.g., into the cell, in the gastrointestinal tract, or across the blood-brain barrier.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!