Global South countries account for two-thirds of WHO Member States and are a crucial voice in negotiating the 'pandemic treaty', which Member States agreed was necessary if the world was to avoid a repeat of the significant inequity that resulted during COVID-19. The negotiation of a pandemic treaty presents an opportunity to recalibrate global health systems and processes for pandemic prevention, preparedness and response. However, for this to eventuate through global solidarity, as many Global South countries have said they expect, then concessions by developed states on issues that they have long protected must occur. It remains to be seen whether the negotiations amount to a rebalancing of power and resources to substantially improve our capacity and capability to address global health threats. Further, while these issues have often been viewed through a dualistic lens between developing and developed countries, these negotiations also reflect the diversity of Global South Member States, some of which are strong voices in, and for, coalitions. Drawing on content analysis techniques, this research describes how Global South countries articulate their expectations, positions and ambitions during treaty negotiations in the lead up to the World Health Assembly in 2024 and discusses exogenous and endogenous factors that contribute to these positions. The analysis found that the pursuit of equity is galvanising for Global South countries, as are their ambitions for the multilateral system not to drive further inequity through the asymmetry of power and influence exercised by developed states. Well-coordinated collective positions from Global South countries in negotiations to date have resulted in traction on contested issues such as technology transfer, production capability, and access and benefits. Additionally, some Global South countries have also used these negotiations to pursue national interests whilst maintaining collective positions in pursuit of equity and global solidarity.
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http://dx.doi.org/10.1371/journal.pgph.0003851 | DOI Listing |
Oncotarget
March 2025
Worldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.
View Article and Find Full Text PDFN Engl J Med
March 2025
Department of Disease Control, London School of Hygiene and Tropical Medicine, London.
Background: Hospital studies suggest that scrub typhus is a leading cause of severe undifferentiated fever in regions across Asia where the disease is endemic, but the population-based incidence of infection and illness has been little studied.
Methods: We conducted a population-based cohort study to assess epidemiologic and clinical characteristics of scrub typhus in 37 villages in Tamil Nadu, India, where the disease is highly endemic. Study participants were visited every 6 to 8 weeks over a period of 2 years; a venous blood sample was obtained from those who had had fever since the last visit.
Ann Intern Med
March 2025
Massachusetts General Hospital, Boston, Massachusetts; Mbarara University of Science and Technology, Mbarara, Uganda; and Kabwohe Clinical Research Center, Kabwohe, Sheema, Uganda (S.A.).
Background: Data on the prevalence of coronary atherosclerotic disease (CAD) in the African region among people with and without HIV are lacking.
Objective: To estimate the prevalence of CAD in Uganda and determine whether well-controlled HIV infection is associated with increased presence or severity of CAD.
Design: Cross-sectional study.
Proc Natl Acad Sci U S A
March 2025
Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation and mechanism of liver fibrosis triggered by chronic HEV infection remain poorly understood. Here, we found that the viral multiple-domain replicase (ORF1) undergoes unique ubiquitin-proteasomal processing leading to formation of the EV-erived MAD ctivator (HDSA), a viral polypeptide lacking putative helicase and RNA polymerase domains.
View Article and Find Full Text PDFPLoS Negl Trop Dis
March 2025
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Trypanosoma cruzi is a single-celled eukaryotic parasite responsible for Chagas disease, a major cause of morbidity and mortality in Central and South America. While the host-pathogen interactions of T. cruzi have been extensively studied in vertebrate models, investigations into its interactions within its insect host remain limited.
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