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RE: Real-World Survival Impact and Utilization of Adjuvant Radiation in Advanced Laryngeal Cancer.
Ear Nose Throat J
March 2025
The Clinical Research Center for Respiratory Diseases of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
The therapeutic armamentarium that has been made available from the beginning of the emergency phase of the COVID-19 pandemic to date is briefly reviewed, and an overview of the real-world clinical evidence published by the Italian medical and scientific community during the last three years is presented herein. Prior to the introduction of a vaccine for SARS-CoV-2, several treatment options were implemented from the onset given the evidence that a "cytokine storm" was present during infection with SARS-CoV-2. However, with the exception of tocilizumab, baricitinib and perhaps anakinra, most studies with anti-cytokine biological agents in patients with severe COVID-19 did not show any significant clinical improvement or decrease in mortality at day 28.
View Article and Find Full Text PDFAssociation between optimum blood glucose level and mortality in critically ill patients with septic shock: A real-world time-series data analysis.
Nurs Crit Care
March 2025
Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
Background: Sepsis remains a significant health challenge in ICU, with septic shock requiring meticulous glycaemic management due to metabolic dysregulation. Existing research highlights the detrimental effects of both hyperglycaemia and hypoglycaemia on septic patient outcomes, emphasizing the need for effective glycaemic control. Despite extensive studies, optimal glycaemic targets in septic shock patients remain contentious and unclear, necessitating further research.
View Article and Find Full Text PDFRight heart failure and mortality in patients undergoing transcatheter tricuspid valve interventions.
Int J Cardiol
March 2025
HerzZentrum Hirslanden, Zurich, Switzerland.
Aims: To assess the association between right heart failure (RHF) and mortality in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve intervention (TTVI), and to determine whether clinical RHF status reduces the survival benefit of successful versus failed TTVI.
Methods And Results: The TriValve International Registry (Transcatheter Tricuspid Valve Therapies) is a multicenter registry collecting data of patients with symptomatic, severe or greater TR undergoing TTVI. The population was stratified according to RHF status defined by the following clinical criteria: history of previous hospitalization for RHF (<1 year) OR presence of signs of RHF (jugular venous distension, ascites, peripheral oedema) OR high dose diuretic (≥125 mg/day of furosemide or equivalent).
Co-occurring impairments in several domains of memory following neonatal hypoxic-ischaemic encephalopathy have real-life implications.
Eur J Paediatr Neurol
March 2025
School of Psychology, University of East London, London, UK. Electronic address:
Background: Neonatal Hypoxic-Ischaemic Encephalopathy (HIE) increases the risk for neurodevelopmental impairment. Information on school-age memory function is limited in children who received hypothermia treatment (TH) for neonatal HIE.
Objectives: To evaluate memory function in school-aged children who had neonatal HIE and TH and survived without major neuromotor impairment.
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