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http://dx.doi.org/10.1007/s40273-025-01475-2 | DOI Listing |
Pharmacoeconomics
March 2025
White Box Health Economics Ltd, Amelia House, Crescent Road, Worthing, West Sussex, UK.
BMC Oral Health
March 2025
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul Medeniyet University, Istanbul, Türkiye.
Aim: This study aims to evaluate the potential of AI-based chatbots in assisting with clinical decision-making in the management of medically complex patients in oral surgery.
Materials And Methods: A team of oral and maxillofacial surgeons developed a pool of open-ended questions de novo. The validity of the questions was assessed using Lawshe's Content Validity Index.
BMC Bioinformatics
March 2025
Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, V5Z 4S6, Canada.
Background: Advanced long-read sequencing technologies, such as those from Oxford Nanopore Technologies and Pacific Biosciences, are finding a wide use in de novo genome sequencing projects. However, long reads typically have higher error rates relative to short reads. If left unaddressed, subsequent genome assemblies may exhibit high base error rates that compromise the reliability of downstream analysis.
View Article and Find Full Text PDFSci Adv
March 2025
Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are primarily genetic in ~20% of patients. Mutations in are the most frequent cause, but it is not understood why there is notable regional pathology. An increased burden of mitochondrial DNA (mtDNA) mutations in ALS-FTLD brains implicates mitochondrial mechanisms; however, it remains unclear how and when these mutations arise.
View Article and Find Full Text PDFBackground: Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050.
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