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Pain and Suffering: The Experience of Patients With Terminal Cancer.
Pain Manag Nurs
March 2025
University Center for Health Sciences, University of Guadalajara, Jalisco, México. Electronic address:
Purpose/objectives: Analyze the meaning of pain and suffering experienced by patients with end-stage cancer from a systemic perspective.
Design: Qualitative study based on General Systems Theory.
Sample/participants: Ten patients with terminal stage cancer were interviewed.
An Overview of Predictive Biomarkers and Detection Approaches for Immunotherapy Response in GI Malignancies.
J Gastroenterol Hepatol
March 2025
Department of Radiology, Yunnan Cancer Center, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
This review provides an in-depth exploration of the evolving role of immunotherapy in gastrointestinal (GI) cancers, with a particular focus on immune checkpoint inhibitors (ICIs) and their associated predictive biomarkers. We present a detailed analysis of established biomarkers, such as PD-L1, microsatellite instability (MSI), tumor mutational burden (TMB), and the tumor microenvironment (TME), as well as emerging biomarkers, including gut microbiota and Epstein-Barr virus (EBV). The predictive value of these biomarkers in guiding clinical decision-making and optimizing immunotherapy outcomes is thoroughly discussed.
View Article and Find Full Text PDFRoles of flgJ in biofilm formation of Vibrio alginolyticus.
J Appl Microbiol
March 2025
Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, Hainan University, Haikou 570228 Hainan Province, China.
Aim: This study aimed to investigate the role of two flgJ genes in flagellar assembly and biofilm regulation in Vibrio alginolyticus.
Methods And Results: To investigate the functions of the flgJ, overexpression and gene knockout techniques were employed. Overexpression of flgJ1 enhanced the strain's growth capacity, leading to a rapid bacterial concentration that initiated biofilm formation.
Analyte heterogeneity analysis as a possible potency parameter for MSC.
Best Pract Res Clin Haematol
December 2024
Mellen Center, Neurological Institute, Cleveland Clinic Foundation, United States.
Mesenchymal stem/stromal cells (MSC) have been transplanted for therapeutic purposes with inconsistent results. MSC preparations are heterogeneous, and this person-to-person heterogeneity may account for the variable clinical outcomes. Additionally, the mechanisms of therapeutic action for MSC are unclear which confounds attempts to understand and identify factors that may account for variable clinical results.
View Article and Find Full Text PDFAsymmetries in the human brain.
Handb Clin Neurol
March 2025
Donders Institute for Brain Cognition Behaviour, Radboud University, Nijmegen, The Netherlands; Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Centre for Neuroimaging Sciences, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Electronic address:
The human brain is an intricate network of cortical regions interconnected by white matter pathways, dynamically supporting cognitive functions. While cortical asymmetries have been consistently reported, the asymmetry of white matter connections remains less explored. This chapter provides a brief overview of asymmetries observed at the cortical, subcortical, cytoarchitectural, and receptor levels before exploring the detailed connectional anatomy of the human brain.
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