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Correction: Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma.
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Medical Oncology Department of Jinling Hospital, Medical School of Nanjing University, 305 ZhongShan Eastern Road, Nanjing, 210002, People's Republic of China.
Foreshadowing haplotype-based methods of the genomics era, it is an old observation that the "junction" between two distinct haplotypes produced by recombination is inherited as a Mendelian marker. In a genealogical context, this recombination-mediated information reflects the persistence of ancestral haplotypes across local genealogical trees in which they do not represent coalescences. We show how these non-coalescing haplotypes ("locally-unary nodes") may be inserted into ancestral recombination graphs (ARGs), a compact but information-rich data structure describing the genealogical relationships among recombinant sequences.
View Article and Find Full Text PDFSUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair.
Mol Cell
March 2025
Birmingham Centre for Genome Biology and Department of Cancer and Genomic Sciences, School of Medicine, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:
The amplitudes of small-modifier protein signaling through ubiquitin and the small ubiquitin-like modifiers, SUMO1-3, are critical to the correct phasing of DNA repair protein accumulation, activity, and clearance and for the completion of mammalian DNA double-strand-break (DSB) repair. However, how SUMO-conjugate signaling in the response is delineated is poorly understood. At the same time, the role of the non-conjugated SUMO protein, SUMO4, has remained enigmatic.
View Article and Find Full Text PDFCorrigendum: Apigenin protects against ischemic stroke by increasing DNA repair.
Front Pharmacol
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College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
[This corrects the article DOI: 10.3389/fphar.2024.
View Article and Find Full Text PDFThermodynamics of hydrogen adsorption on ruthenium surfaces: a density functional theory study.
Phys Chem Chem Phys
March 2025
School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Within the framework of the application of liquid organic hydrogen carriers (LOHC) to store, transport and re-generate hydrogen, ruthenium (Ru) is by far the most widely used catalyst. In its natural bulk state, the most abundant phase observed is the hexagonal close-packed () phase, but experimental studies on nanoparticles have shown that the face-centred cubic () phases are also present and are highly active in catalytic reactions. In this study, we have carried out calculations based on the density functional theory, with the generalized gradient approximation and long-range dispersion corrections, to investigate the behaviour of hydrogen adsorption at the Ru (001), (011) and (111) surfaces.
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