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The relationship between brain and visceral asymmetry: Evidence from situs inversus in humans.
Handb Clin Neurol
March 2025
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. Electronic address:
This review examines the relationship between visceral and brain asymmetry and explores whether their alignment observed in some vertebrate species also exists in humans. While the development of visceral and brain asymmetry may have occurred for different reasons, it is possible that the basic mechanisms for left-right differentiation of the visceral system were duplicated in the brain. We describe the main phenotypical anomalies and the general mechanism of left-right differentiation in vertebrates, followed by a systematic review of available human studies on behavioral and brain asymmetry in individuals with reversed visceral organization.
View Article and Find Full Text PDFAssessing the link of malnutrition with diabetes and mortality risk in heart failure patients.
ESC Heart Fail
March 2025
Department of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Aims: Malnutrition is increasingly recognized as a significant factor influencing the clinical outcomes of patients with heart failure (HF). Diabetes exacerbates risks like hospitalizations and mortality due to cardiovascular complications. The aim of this study was to explore the association of malnutrition with diabetes and its prognostic impact on all-cause and cardiovascular mortality in patients with HF, using the nutritional assessment tools, controlling nutritional status (CONUT) score and geriatric nutritional risk index (GNRI).
View Article and Find Full Text PDFShared Pathophysiological Mechanisms and Genetic Factors in Early Menarche and Polycystic Ovary Syndrome.
J Neurosci
March 2025
Discipline of Endocrinology & Metabolism, Department of Internal Medicine, University of Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Sao Paulo 01246 903, Brazil
Early age at menarche (early AAM) and polycystic ovary syndrome (PCOS) are reproductive and metabolic disorders with overlapping pathophysiological and genetic features. Epidemiological studies suggest a link between these two conditions, both of which are characterized by dysregulation of the neuroendocrine pathways that control pulsatile gonadotropin-releasing hormone secretion, thus affecting gonadotropin release, particularly luteinizing hormone secretion. A common pathophysiology involving positive energy balance and abnormal metabolic status is evident in both disorders.
View Article and Find Full Text PDFCystatin C is associated with osteoporosis and fractures: An observational study based on Mendelian randomization analysis.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Research for Genetic Epidemiology and Genomics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou Jiangsu 215123, China.
Objectives: Osteoporosis is characterized by decreased bone mass and damaged bone microstructure, often leading to fragility fractures. Low bone mineral density is a key risk factor for fractures. Serum cystatin C (CysC), an endogenous marker of glomerular filtration rate, is negatively correlated with bone mineral density and may be a potential risk factor for osteoporosis.
View Article and Find Full Text PDFPatient experience and primary care teams: a cross-sectional survey of French elderly patients.
BMJ Open
March 2025
Department of Primary Care Federative, Nantes Universite, Nantes, France.
Objective: To assess whether patient experience is better for patients followed in a primary care team (PCT) than for patients with traditional follow-up in usual care.
Design: A cross-sectional survey based on a self-administered questionnaire.
Setting: Pays de la Loire geographical area (located on the French west coast).
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