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Treat-And-Extend Versus Pro Re Nata Regimen of Intravitreal Conbercept Injection for Neovascular Age-Related Macular Degeneration: Results from COCOA, a Prospective, Open-Label, Multicenter, Randomized Phase IV Clinical Trial.
Semin Ophthalmol
March 2025
Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Purpose: To evaluate and contrast the effectiveness and safety of two conbercept treatment protocols-a three-dose treat-and-extend (3+T&E) regimen and a three-dose pro re nata (3+PRN) regimen-in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).
Methods: Eligible patients, who had not undergone anti-VEGF intraocular injections within 3 months prior to enrollment, were randomly assigned to either the 3+T&E or 3+PRN regimen. The 3+T&E group received at least three monthly injections, with subsequent visit intervals extended based on disease activity assessment.
Prurigo pigmentosa following laparoscopic sleeve gastrectomy: a case report.
J Surg Case Rep
March 2025
Department of General Surgery, Prince Sultan Military Medical City, Riyadh Makkah Al Mukarramah Road, As Sulimaniyah, Riyadh, 12233, Saudi Arabia.
Prurigo pigmentosa (PP) is a rare dermatological condition with an unclear, often idiopathic etiology, but recent evidence points to a potential link between the disease and metabolic changes, particularly those associated with ketosis. It typically presents as a pruritic, erythematous rash, mainly affecting the trunk and neck, and often features hyperpigmented macules and plaques. The onset of PP has been associated with various factors, including fasting, dieting, and certain metabolic disorders.
View Article and Find Full Text PDFBackground And Aims: Alzheimer's disease (AD) is a widespread neurodegenerative condition that has a growing impact on a global scale. This study aims to examine the relationship between cerebral blood flow (CBF) and the synaptic biomarker growth-associated protein 43 (GAP-43) through the utilization of arterial spin labeling (ASL). The research identified noteworthy correlations between cerebrospinal fluid (CSF) GAP-43 levels, CBF, and cognitive composite scores, especially among participants with mild cognitive impairment (MCI) who possess the APOE-ε4 gene.
View Article and Find Full Text PDFCorrigendum: Macrophage variants in laboratory research: most are well done, but some are RAW.
Front Cell Infect Microbiol
February 2025
Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
[This corrects the article DOI: 10.3389/fcimb.2024.
View Article and Find Full Text PDFUnraveling the impact of laser refractive surgery on corneal ectasia: an study.
Front Bioeng Biotechnol
February 2025
Aragon Institute of Research Engineering (I3A), Universidad de Zaragoza, Zaragoza, Spain.
Introduction: Laser refractive surgeries are a safe option for low-to-moderate refractive corrections, providing excellent visual outcomes. Over the years, various procedures have been introduced into clinical practice, but the most performed today remain Photorefractive Keratectomy (PRK), Laser Keratomileusis (LASIK), and Small Incision Lenticule Extraction (SMILE). Although laser refractive treatments are considered safe, clinicians have focused on the risk of post-surgical ectasia, a rare but serious complication.
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