Purpose Of Review: We review the utility of coronary artery calcium (CAC) scoring in personalized risk assessment and initiation of cardiovascular disease risk modifying therapy.
Recent Findings: Many populations - including South Asians, patients with cancer, patients with human immunodeficiency virus (HIV), younger patients, and elderly patients - were not included during the conception of the current risk stratification tools. CAC scoring may allow clinicians to risk-stratify these individuals and help initiate preventive therapy in higher risk populations. Furthermore, CAC scoring may be able to be integrated into current imaging practices to allow for more ubiquitous and equitable screening practices.
Summary: CAC scoring is an additional, objective metric that may allow for nuanced and personalized risk assessment of future atherosclerotic cardiovascular disease (ASCVD) events.
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http://dx.doi.org/10.1097/HCO.0000000000001216 | DOI Listing |
Curr Opin Cardiol
March 2025
Ciccarone Center for the Prevention of Cardiovascular Disease, John Hopkins Hospital, Baltimore, Maryland, USA.
Purpose Of Review: We review the utility of coronary artery calcium (CAC) scoring in personalized risk assessment and initiation of cardiovascular disease risk modifying therapy.
Recent Findings: Many populations - including South Asians, patients with cancer, patients with human immunodeficiency virus (HIV), younger patients, and elderly patients - were not included during the conception of the current risk stratification tools. CAC scoring may allow clinicians to risk-stratify these individuals and help initiate preventive therapy in higher risk populations.
CJC Open
February 2025
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Background: The impact of coronary artery calcium (CAC) scoring on downstream resource utilisation and outcomes remains unclear, especially in those with zero CAC.
Methods: Consecutive CAC scores from two academic hospitals in Toronto, Ontario, were linked to population-based databases. Subjects with zero CAC without previous cardiovascular disease were propensity score matched with a non-CAC-tested control group for age, sex, cardiovascular risk factors, and comorbidities.
Am J Prev Cardiol
March 2025
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Inflammation plays an important role in the pathophysiology of atherosclerosis. However, inflammatory biomarkers have only been weakly associated with coronary artery calcium (CAC), a representative measure of subclinical atherosclerosis. Moreover, few studies explored extra-coronary calcium (ECC) in this context.
View Article and Find Full Text PDFAm J Cardiol
March 2025
Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:
The clinical significance of diabetes mellitus (DM) on the cardiovascular disease in the zero coronary artery calcium (CAC) group is not well studied. This study investigated the impact of DM in an asymptomatic population with zero CAC scores. Overall, 9269 adults who received coronary computed tomography angiography (CCTA) scans for coronary disease evaluation during a general medical checkup were initially selected.
View Article and Find Full Text PDFRev Port Cardiol
March 2025
NOVA Medical School, Faculdade de Ciências Médicas, Campo dos Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
Introduction And Objectives: Decoding the genetic basis of coronary artery disease (CAD) through an intermediate phenotype - coronary calcification - can help us to better understand this deadly disease and enable the creation of better therapeutic strategies. This work aims to assess the relationship between a set of single nucleotide polymorphisms (SNPs) previously associated with CAD and coronary artery calcium (CAC) score in a Portuguese asymptomatic population.
Methods: A prospective study was conducted in a cohort of 1284 subjects (aged 59.
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