Purpose Of Review: This review focuses on the latest information regarding the role of complementary feeding practices and food allergen introduction in the prevention of food allergies.
Recent Findings: Early introduction of food allergens for food allergy prevention is recommended by food allergy prevention guidelines and is supported by the latest randomized controlled trials. Diet diversity is recommended, supported by the latest studies from Asia. A European study indicated that diet diversity after the first year of life may still be important for food allergy prevention. The latest systematic reviews indicate there may be an association between ultra-processed food intake and food allergy development. Plant based foods and fiber play an important role in modulating the gut microbiome which has been associated with reduced food allergy outcomes. However, increased intake of food allergens within a diverse diet raises questions about excessive calorie and protein intake but can be managed by focusing on infant satiety cues.
Summary: The latest studies clearly indicate and further supports that introduction of food allergies should not be delayed once complementary feeding is commenced. A diverse diet is recommended to further support the prevention of food allergies.
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http://dx.doi.org/10.1097/MCO.0000000000001126 | DOI Listing |
J Agric Food Chem
March 2025
SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Covalent modification is an effective strategy for reducing allergenicity to individual allergens, but there are few studies on this strategy modifying specific amino acids within epitopes under the influence of food matrix. This study used fucoidan to covalently modify shrimp () and combined mass spectrometry and bioinformatics techniques to explore epitope modification. The results showed that lower concentrations (<2.
View Article and Find Full Text PDFJ Immunol
February 2025
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.
Food allergy has had a rapid rise in prevalence, and thus it is important to identify approaches to limit the development of food allergy early in life. Because maternal dietary supplementation with α-tocopherol (α-T), an isoform of vitamin E, during pregnancy and nursing increases neonate plasma levels of α-T and can limit neonate development of other allergies, we hypothesized that α-T can limit development of food allergy. To assess this, male mice with mutations in their skin barrier genes (FT-/- mice) were mated with wild-type females that received a diet supplemented with α-tocopherol or a control diet.
View Article and Find Full Text PDFJ Immunol
March 2025
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.
Food allergy can be life threatening and often develops early in life, especially in infants and children with atopic dermatitis. Food allergy is induced in neonatal mice with skin barrier mutations (Flaky Tail, FT+/- mice with filaggrin and mattrin gene mutations) by epicutaneous sensitization with co-exposures to the food allergen peanut extract (PNE), the environmental allergen Alternaria alternata (Alt), and detergent (4% SDS); oral PNE-challenge induces anaphylaxis. Sensitization in these neonates also induces eosinophil infiltration into the skin and elevates skin expression of eotaxins (CCL11 and CCL24).
View Article and Find Full Text PDFCurr Opin Clin Nutr Metab Care
March 2025
Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Purpose Of Review: This review focuses on the latest information regarding the role of complementary feeding practices and food allergen introduction in the prevention of food allergies.
Recent Findings: Early introduction of food allergens for food allergy prevention is recommended by food allergy prevention guidelines and is supported by the latest randomized controlled trials. Diet diversity is recommended, supported by the latest studies from Asia.
Cells
February 2025
Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Cow's milk allergy (CMA) is the most common food allergy in infants. This study aimed to identify peptide biomarkers predictive of tolerance in a Spanish population of children with CMA. We investigated specific IgE and IgG4 binding to sequential epitopes of the five major CM allergens (α-s1-, α-s2-, β-, and κ-caseins as well as β-lactoglobulin) using a microarray-based immunoassay.
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