Lifei Qingchang Tang attenuates acute lung injury the NF-κB and MAPK signaling pathways.

Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. , LFQCT reduced intracellular Ca, ROS, and NO in LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, and IL-6), iNOS, and COX-2, and blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, and p38. It also inhibited p65 activation and nuclear translocation. , LFQCT attenuated ALI in mice by reducing cytokines in serum, BALF, and lung tissues, improving pulmonary function and survival rates, being a potential new treatment.