This paper provides a thorough examination of aging-related diseases, exploring into the intricate molecular mechanisms that underline their development and progression. It explores cutting-edge therapeutic interventions aimed at addressing these conditions, with a particular focus on non-pharmacological approaches such as personalized lifestyle modifications, cognitive enhancement strategies, and robust social engagement initiatives. Additionally, it highlights emerging modalities including gene therapy and precision medicine as promising avenues for mitigating the challenges associated with age-related ailments. Despite significant strides in research, persistent barriers such as limited healthcare access and regulatory complexities continue to impede the widespread implementation of these innovative approaches. Overcoming these obstacles requires collaborative efforts to promote health equity and ensure equitable access to transformative treatments. By advancing our understanding and embracing innovative paradigms, we can catalyze a profound transformation toward healthier aging trajectories. Through sustained interdisciplinary collaborations, rigorous research endeavors, and proactive advocacy initiatives, we can aspire to cultivate a future where aging is synonymous with vitality, dignity, and enhanced well-being for individuals worldwide.
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http://dx.doi.org/10.14336/AD.2024.0560 | DOI Listing |
Aging Dis
February 2025
International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia.
This paper provides a thorough examination of aging-related diseases, exploring into the intricate molecular mechanisms that underline their development and progression. It explores cutting-edge therapeutic interventions aimed at addressing these conditions, with a particular focus on non-pharmacological approaches such as personalized lifestyle modifications, cognitive enhancement strategies, and robust social engagement initiatives. Additionally, it highlights emerging modalities including gene therapy and precision medicine as promising avenues for mitigating the challenges associated with age-related ailments.
View Article and Find Full Text PDFHeliyon
February 2025
Department of Geriatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, PR China.
Background: Magnesium is a vital mineral that plays a crucial role in various physiological processes, and its imbalance has been associated with many chronic aging-related diseases. Traditional assessment methods are insufficient, and the Magnesium Depletion Score (MDS) has been proposed as a significant indicator. Klotho, a transmembrane protein, is involved in aging regulation and oxidative stress modulation.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations.
View Article and Find Full Text PDFBiogerontology
March 2025
Department of Biotechnology, Faculty of Science and Technology (FOST), University of Central Punjab (UCP), 1- Khayaban-E-Jinnah Road, Johar Town Lahore, Pakistan.
Aging is a principal driver of cardiomyopathy, characterized by mitochondrial dysfunction, oxidative stress, and progressive telomere shortening in cardiomyocytes. These pathological changes impair cellular bioenergetics and regenerative capacity, accelerating cardiac deterioration. However, targeted interventions to mitigate these effects remain limited.
View Article and Find Full Text PDFJ Ginseng Res
March 2025
Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Background: Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.
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