A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.04 ± 0.38 μM). This study enriched the structural diversity of alkaloids in and provided further clues for searching new antidiabetic agents from natural sources.
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A new pyrrolopyrazine alkaloid from the fruit of .
J Asian Nat Prod Res
March 2025
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou405600, China.
A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.
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Ann Bot
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IFEVA, Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina.
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Biodiversity Unit, University of Turku, Turku, Finland.
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Article Synopsis
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