Pharmacologic inhibition of RNA polymerase I activity represents a new therapeutic approach for Ewing sarcoma. This is the first time key components of the ribosome biogenesis pathway have been linked to Ewing sarcoma biology.
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Targeting RNA Polymerase I in Ewing Sarcoma Treatment.
Cancer Sci
March 2025
Department of Biology, Jacksonville State University, Jacksonville, Alabama, USA.
Pharmacologic inhibition of RNA polymerase I activity represents a new therapeutic approach for Ewing sarcoma. This is the first time key components of the ribosome biogenesis pathway have been linked to Ewing sarcoma biology.
View Article and Find Full Text PDFExtra Skeletal Ewing's Sarcoma of Sino Nasal Tract-A Rare Entity a Case Report.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Radiodiagnosis, IGMC, Shimla, 171001 Himachal Pradesh India.
Ewing's sarcoma is a rare and highly malignant tumour predominantly affecting the bones. Extra skeletal Ewing's sarcoma of Sino nasal tract, encompassing the nasal cavity and paranasal sinuses is an exceedingly rare location for this tumour. We present a case of a 16 year-old boy who presented with right nasal obstruction, epistaxis and right facial swelling since 3 months.
View Article and Find Full Text PDFEWS-RNA Binding Protein 1: Structural Insights into Ewing Sarcoma by Conformational Dynamics Investigations.
Curr Cancer Drug Targets
March 2025
The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Background: Prior research has demonstrated that proteins play a significant role in the prognosis and treatments of various sarcomas, including Ewing sarcoma through the interplay of downstream signaling cascades. However, there is limited understanding about the strcucture conformation of EWSR1 and its structural implication in the prognosis of Ews-ing Sarcoma by interaction with RNA molecules.
Aims: The primary goal of ongoing research is to determine how EWSR1 contributes to Ewing sarcoma.
The Combination of PARP and Topoisomerase 1 Inhibitors Improves Radiation Therapy for Ewing Sarcoma.
Cancer Sci
March 2025
Department of Chemical Biology and Therapeutics, SJCRH, Memphis, Tennessee, USA.
Although primary tumor control rates after surgery and/or radiation therapy (RT) are generally high in patients with Ewing sarcoma (EWS), those with unresectable tumors have failure rates approaching 30% and experience poorer outcomes. Additionally, although metastatic site irradiation is associated with improved survival, dose, and volume effects influence the long-term toxicity risk. Consequently, it is important to identify novel systemic agents to enhance the therapeutic ratio of RT.
View Article and Find Full Text PDFProtocol for single-cell RNA sequencing and spatial transcriptomics of bladder Ewing sarcoma.
STAR Protoc
March 2025
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China. Electronic address:
Single-cell RNA sequencing provides a deep understanding of gene expression patterns at the single-cell level, enabling researchers to study cellular heterogeneity and differentiation. Spatial transcriptomics, meanwhile, delivers spatial visualization and quantitative analysis of tissue sections. Here, we introduce a protocol to isolate single cells and obtain high-quality spatial transcriptomics data from bladder Ewing sarcoma tissue.
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