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Pathophysiological insights into the successful treatment of EBV-positive hydroa vacciniforme lymphoproliferative disorder with hydroxychloroquine.
J Dtsch Dermatol Ges
March 2025
Department of Dermatology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Natural killer cells in the lung: novel insight and future challenge in the airway diseases.
ERJ Open Res
March 2025
Respiratory Diseases Unit, Department of Medical Sciences, Surgery and Neurosciences, Siena University Hospital, Siena, Italy.
Natural killer (NK) cells are innate lymphoid cells which are present in the lung as circulating and resident cells. They are key players both in airway surveillance and in crosstalk with (COPD) pathogenesis, and they seem to contribute to the development of bronchiectasis. In asthma, NK cell dysfunction was observed mainly in severe forms, and it can lead to a biased type-2 immune response and failure in the resolution of eosinophilic inflammation that characterise both allergic and eosinophilic phenotypes.
View Article and Find Full Text PDFAssociation of Sarcopenia and Urinary Incontinence in Adult Women Aged Less Than 60 years.
Int J Womens Health
March 2025
Department of Urology, Changzhou Third People's Hospital, Changzhou, Jiangsu, People's Republic of China.
Purpose: This study aimed to explore the association between sarcopenia and urinary incontinence in adult women younger than 60 and provide insights into their pathophysiological mechanisms.
Patients And Methods: The study included 4,553 adult female participants aged <60, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database between 2011 and 2018. The appendicular skeletal muscle mass index (ASMI) was assessed using dual-energy X-ray absorptiometry, and sarcopenia was determined based on the resulting ASMI values (< 0.
Introduction: As a late proinflammatory factor, the role of High mobility group box 1 (HMGB-1) in nervous system inflammation has been widely studied. The inflammatory response mediated by HMGB-1 plays an important role in the pathophysiological mechanism of depression. This study aimed to investigate the antidepressant effects of forced running on chronic unpredictable mild stress (CUMS) mice by examining the impact on hippocampal HMGB-1.
View Article and Find Full Text PDFGSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL.
Proc Natl Acad Sci U S A
March 2025
Department of Otolaryngology, Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China.
Inflammation is among the known causes of cisplatin-induced hearing loss (CIHL), but its exact pathophysiological mechanisms remain unclear. Herein, we demonstrated that pyroptosis-a recently identified inflammatory type of regulated cell death dependent on gasdermin D (GSDMD)-was activated in the cochleae of cisplatin-treated mice, causing CIHL. Meanwhile, treatment with the GSDMD inhibitor necrosulfonamide alleviated CIHL in these mice.
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