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Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer.
JAMA Netw Open
March 2025
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Importance: Frailty assessed at a single time point is associated with mortality in older women with breast cancer. Little is known about how changes in frailty following cancer treatment initiation affect mortality.
Objective: To evaluate the association between claims-based frailty trajectories following adjuvant chemotherapy initiation and 5-year mortality in older women with stage I to III breast cancer.
Outcomes of Older Adults With Delirium Discharged From the Emergency Department.
Ann Emerg Med
March 2025
Department of Emergency Medicine, Mayo Clinic, Rochester, MN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN. Electronic address:
Study Objective: To compare 30-day mortality and return emergency department (ED) visits among older adults with delirium who are discharged home with those discharged home without delirium and those who are admitted to the hospital with and without delirium.
Methods: Adults aged 75 and older years were assessed for delirium using the Delirium Triage Screen followed by the Brief Confusion Assessment Method. We evaluated outcomes including return visits and 30-day mortality.
Is Frailty the Geriatric Troponin?
J Am Geriatr Soc
March 2025
McGill University Health Centre, McGill University, Montreal, Canada.
The Cholinergic Receptor Nicotinic α3 Was Reduced in the Hippocampus of Early Cognitively Impaired Adult Male Mice and Upregulated by Nicotine and Cytisine in HT22 Cells.
Cells
February 2025
Advanced Research Center for Geriatric and Gerontology, Akita University, Akita 010-8543, Japan.
Ageing is a major risk factor for cognitive and physical decline, but its mechanisms remain poorly understood. This study aimed to detect early cognitive and physical changes, and to analyze the pathway involved by monitoring two groups of mice: a young and an adult group. The study has identified the types of molecules involved in the hippocampus.
View Article and Find Full Text PDFAnalysis of the Correlation between Frailty Index, Clinical Characteristics, Use of Anti-Epileptic Drug, and Prognosis in Elderly Patients with Epilepsy.
Actas Esp Psiquiatr
March 2025
Department of Geriatrics, Affiliated Mindong Hospital, Fujian Medical University, 355000 Fu'an, Fujian, China.
Background: Epilepsy is a common neurological disorder among the elderly, often leading to significant morbidity. Therefore, it is necessary to study the correlation between the frailty index, clinical characteristics of epilepsy, use of anti-epileptic drug, and the prognosis of elderly patients with epilepsy.
Methods: This retrospective study included 106 elderly patients with epilepsy who were treated at the Affiliated Mindong Hospital, Fujian Medical University, China, between January 2018 and December 2022.
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