Deprotonated trimethylsilylethanol is an excellent nucleophile for Matteson homologations. It can be introduced in high yields and the products are stable under the usual basic reaction conditions. After two further homologation steps, the protective group is automatically cleaved off via a six-membered ring O-B coordination, providing highly substituted tetrahydrofurans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.202500560 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Stereoselective Syntheses of Highly Substituted Tetrahydrofurans based on Matteson Homologations.
Chemistry
March 2025
Organic Chemistry I, Saarland University, Campus C4.2, D-, 66123, Saarbrücken.
Deprotonated trimethylsilylethanol is an excellent nucleophile for Matteson homologations. It can be introduced in high yields and the products are stable under the usual basic reaction conditions. After two further homologation steps, the protective group is automatically cleaved off via a six-membered ring O-B coordination, providing highly substituted tetrahydrofurans.
View Article and Find Full Text PDFGiant Capacitive Energy-Storage in BaTiO-Based Fine-Grained Relaxors via Local Polarization Enhancement.
Adv Mater
March 2025
Beijing Advanced Innovation Center for Materials Genome Engineering, Department of Applied Physics, University of Science and Technology Beijing, Beijing, 100083, China.
Pb-free dielectric energy storage capacitors are core components in advanced pulse-power electronic systems and devices. However, the relatively low energy density (W) for the industrial pillar BaTiO (BT)-based capacitors remains a significant obstacle for their cutting-edge applications, due to their low intrinsic polarization and breakdown strength (E). Herein, through chemical composition and local structure design, a giant W of 15.
View Article and Find Full Text PDFHighly regio- and stereo-controlled synthesis of ()-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes hydroalkynylation of alkynyl thioethers.
Org Biomol Chem
March 2025
Department of Chemistry and Applied Chemistry, Saga University, Honjyo-machi 1, Saga 840-8502, Japan.
The palladium-catalyzed addition of terminal acetylenes to 1-(trifluoromethyl)-2-(phenylthiol)ethyne, generated , proceeded readily to afford the corresponding ()-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes in good to high yields with excellent regio- and stereocontrol under mild conditions.
View Article and Find Full Text PDFArene and Heteroarene Functionalization Enabled by Organic Photoredox Catalysis.
Acc Chem Res
March 2025
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 United States.
ConspectusAromatic functionalization reactions are some of the most fundamental transformations in organic chemistry and have been a mainstay of chemical synthesis for over a century. Reactions such as electrophilic and nucleophilic aromatic substitution (EAS and SAr, respectively) represent the two most fundamental reaction classes for arene elaboration and still today typify the most utilized methods for aromatic functionalization. Despite the reliable reactivity accessed by these venerable transformations, the chemical space that can be accessed by EAS and SAr reactions is inherently limited due to the electronic requirements of the substrate.
View Article and Find Full Text PDFFunctional dissection of the C-terminal domain of rabies virus RNA polymerase L protein.
J Virol
March 2025
Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Unlabelled: The rabies virus large (L) protein interacts with its cofactor phosphoprotein (P protein) to function as an RNA-dependent RNA polymerase (RdRp). The C-terminal domain (CTD) of the L protein plays a critical role in P protein binding. We previously reported that the highly conserved NPYNE sequence in the hydrophilic region of the CTD (positions 1929-1933 of the L protein [L1929-1933]) is important for both P protein binding and RdRp function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!