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http://dx.doi.org/10.1002/ijc.35393 | DOI Listing |
Drugs
March 2025
Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.
Revumenib (Revuforj) is an oral, first-in-class menin inhibitor developed by Syndax Pharmaceuticals for the treatment of KMT2A-rearranged (KMT2Ar) acute leukaemia, NPM1-mutated (NPM1m) acute myeloid leukaemia (AML) and solid tumours. The interaction between menin and the KMT2A protein complex leads to aberrant gene expression, driving leukaemogenic transcription. By blocking this interaction, revumenib promotes differentiation and exerts antileukaemic activity in KMT2Ar acute leukaemias and other menin inhibition-sensitive leukaemias.
View Article and Find Full Text PDFInt J Cancer
March 2025
Anal Neoplasia Clinic, Research, and Education Center, University of California, San Francisco, California, USA.
Int J Cancer
March 2025
Surgical Science Department, University of Turin, Città della Salute e della Scienza di Torino, Turin, Italy.
Int J Health Plann Manage
March 2025
IANPHI, Saint-Maurice, France.
Following the announcement by the new American administration of a pause and review of funding to international aid programmes, we comment on the potential effect on global health security and argue for increased recognition of the role of National Public Health Institutes (NPHIs) to mitigate the impacts.
View Article and Find Full Text PDFJ Pediatr Urol
February 2025
Department of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, 411018, Maharashtra, India; Department of Public Health Dentistry, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, 411018, Maharashtra, India. Electronic address:
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