Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, is a critical factor in the pathogenesis of a wide range of diseases. The excessive accumulation of ROS can cause severe cellular damage, leading to tissue dysfunction and disease progression. The development of nanomaterials with antioxidant properties presents a promising strategy for addressing this challenge. Herein, we report the fabrication of albumin-biomineralized copper nanoclusters (BCNCs) as a novel antioxidant platform and evaluate their effectiveness in combating oxidative stress. Our results show that BCNCs exhibit potent ROS scavenging abilities and protect cells from oxidative stress-induced damage, highlighting their potential as an effective therapeutic strategy for oxidative stress-related diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3390/nano15050360 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rational Fabrication of Copper Nanoclusters and In Vitro Study of Antioxidant Property.
Nanomaterials (Basel)
February 2025
School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-Lane Xiangshan, Hangzhou 310024, China.
Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, is a critical factor in the pathogenesis of a wide range of diseases. The excessive accumulation of ROS can cause severe cellular damage, leading to tissue dysfunction and disease progression. The development of nanomaterials with antioxidant properties presents a promising strategy for addressing this challenge.
View Article and Find Full Text PDFCysteine-assisted synthesis of copper nanoclusters for construction of FRET-based ratiometric sensor for visual detection of alkaline phosphatase.
Talanta
March 2025
Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Medicine, Linyi University, Linyi, 276005, PR China. Electronic address:
Abnormal alkaline phosphatase (ALP) levels in the human body are closely associated with various diseases, particularly hepatobiliary diseases and bone diseases. Herein, we constructed a ratiometric sensor based on Förster resonance energy transfer (FRET) using strongly photoluminescent copper nanoclusters (Cu NCs) for the detection of ALP with high sensitivity and specificity. The cysteine-stabilized Cu NCs (Cys-Cu NCs) were synthesized through a ligand-exchange reaction and core-size etching focusing, which displayed bright photoluminescence (PL) with a quantum yield (QY) of 10.
View Article and Find Full Text PDFSmartphone-assisted copper nanoclusters fluorescent sensing platform for visual determination of Congo red.
Colloids Surf B Biointerfaces
March 2025
College of Chemistry and Materials, Taiyuan Normal University, Jinzhong 030619, PR China.
In order to realize efficient detection of Congo red, fluorescence analytical method were adopted and investigated systematically. Based on the superior properties of papain and excellent performance of copper nanoclusters, papain stabilized copper nanoclusters (Cu NCs@PP) with blue fluorescence were rapidly synthesized via a one-pot method. The spherical Cu NCs@PP uniformly dispersed with an average size of about 2.
View Article and Find Full Text PDFFe(III)-quenched cysteine-capped copper nanoclusters as a selective fluorescence turn-on sensor for valine: A potential cancer biomarker candidate.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India; International Inter University Centre for Sensing and Imaging (IIUCSI), Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India. Electronic address:
This study introduces a fluorescence turn-on sensor for the selective detection of valine, an amino acid increasingly recognized as a potential biomarker in cancer diagnostics, using iron(III) (Fe) quenched L-cysteine capped copper nanoclusters (L-cys@CuNCs) based on the paramagnetic quenching mechanism of Fe. The L-cys@CuNCs, synthesized through a one-pot hydrothermal method, exhibit stable green fluorescence, high photostability and a detection limit of 3.00 µM for valine.
View Article and Find Full Text PDFDeciphering Electrocatalytic Activity in Cu Nanoclusters: Interplay Between Structural Confinement and Ligands Environment.
Small
March 2025
Research Institute for Science & Technology, Tokyo University of Science, Tokyo, 162-8601, Japan.
Ligand-protected copper nanoclusters (Cu NCs) with atomic precision have emerged rapidly due to their fascinating structural architectures and versatile catalytic properties, making them ideal for investigating structure-activity relationships. Despite their potential, challenges such as stability issues and limited structural diversity have restricted deeper exploration. In this study, three distinct Cu NCs are synthesized using a one-pot reduction strategy by carefully modifying reaction conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!