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Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples.
Sci Adv
March 2025
Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Glioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site. To investigate the GBM-specific 3D genome organization and its heterogeneity, we conducted Hi-C experiments in 21 GBM samples from nine patients, along with three normal brain samples.
View Article and Find Full Text PDFUtilization of long-acting contraceptive methods and associated factor among women of reproductive age in East Africa: A multi-level analysis of recent Demographic and Health Surveys.
PLoS One
March 2025
Department of Optometry, School of Medicine, University of Gondar, Comprehensive Specialized Hospital, Gondar, Ethiopia.
Background: Comprehensive family planning is essential for reproductive health, allowing individuals to make informed choices about family size and enhancing maternal and child health. Long-acting contraceptives (LACs) are known for their high efficacy and consistent use. This study examines the prevalence and determinants of LAC utilization among women of reproductive-age in 11 East African countries.
View Article and Find Full Text PDFWomen's attitudes towards physical intimate partner violence in India: Trends, patterns, and determinants.
PLoS One
March 2025
Department of Liberal Arts, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India.
Women's attitudes towards physical intimate partner violence are a major determinant of the likelihood of their exposure to physical intimate partner violence. In this study, we scrutinize the third, fourth, and fifth rounds of the National Family Health Survey using descriptive analyses and logistic regression models to understand the trends, patterns, and drivers of women's attitudes towards physical intimate partner violence across various demographic and socioeconomic groups in India. Our findings reveal a noticeable decline in the level of women's acceptability of physical intimate partner violence over the past 15 years, albeit at a slow pace.
View Article and Find Full Text PDFPrognostic significance of asymmetric dimethyl arginine level in pediatric patients with COVID-19 infection and MIS-C.
Eur J Pediatr
March 2025
Departments of Pediatric Infectious Diseases, Faculty of Medicine Hospital, Necmettin Erbakan University, Konya, Turkey.
Unlabelled: Coronavirus disease 2019 (COVID-19) and COVID-19-related multisystem inflammatory syndrome in children (MIS-C) is known to be a life-threatening health problem worldwide. The study investigates the potential relationship between asymmetric dimethylarginine (ADMA) levels and disease severity in such conditions. We conducted an observational, prospective study between July 2021 and January 2022.
View Article and Find Full Text PDFRetinal Microvascular Biomarker Assessment With Automated Algorithm and Semiautomated Software in the Montrachet Dataset.
Transl Vis Sci Technol
March 2025
Ophthalmology Department, Dijon University Hospital, Dijon, France.
Purpose: To compare automated and semiautomated methods for the measurement of retinal microvascular biomarkers: the automated retinal vascular morphology (AutoMorph) algorithm and the Singapore "I" Vessel Assessment (SIVA) software.
Methods: Analysis of retinal fundus photographs centered on optic discs from the population-based Montrachet Study of adults aged 75 years and older. Comparison and agreement evaluation with intraclass correlation coefficients (ICCs) between SIVA and AutoMorph measures of the central retinal venular and arteriolar equivalent, arteriolar-venular ratio, and fractal dimension.
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