Purpose: The purpose of this review is to highlight important ethical aspects of informed consent in the unconsentable patient or participant.
Recent Findings: Recent research and guidelines stress the need for detailed and honest communication respecting patient autonomy and the standards of informed consent. Emphasis is placed on full disclosure and guidance. This includes informing patients and participants of the use of data collected and individuals involved in therapy or research.
Summary: Informed consent is a legal process and there are standards that must be maintained. Whether in clinical practice before a procedure or therapy, or within research participation, informed consent must be obtained from individuals with mental capacity. However, in those who lack such capacity, an emergency exception can be used in dire situations but only once a concerted effort is made to locate a surrogate. Even so, the decision made must be in keeping with respecting the individual's prior known wishes.
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http://dx.doi.org/10.1097/ACO.0000000000001480 | DOI Listing |
Indian J Gastroenterol
March 2025
Departments of Pediatrics, Giza, Egypt.
Background And Objectives: Kasai-portoenterostomy (KPE) is the initial attempt to restore the bile flow and salvage the native liver in biliary atresia (BA) patients. Cholangitis is a frequent complication after KPE and adequate treatment impacts the long-term outcome. The aim of our study is to assess the severity of cholangitis episodes in a cohort of BA patients post KPE, identify the causative agents, using several diagnostic methods, as well as to assess the tolerability and efficacy of our antimicrobial protocol.
View Article and Find Full Text PDFJ Nephrol
March 2025
Nephrology Dialysis and Kidney Transplant Unit, Azienda Ospedaliero Universitaria di Modena, Via del pozzo 71, 41122, Modena, Italy.
The adsorption technique has opened a new frontier in the field of purification through hemodialysis. This technique has proved to be effective in removing uremic toxins previously deemed inaccessible due to their size or charge, as well as to their molecular interactions with blood proteins. In this context, this review provides a detailed explanation of the role of Polyester-polymer alloy (PEPA®) membranes and hemodiafiltration with endogenous reinfusion.
View Article and Find Full Text PDFOphthalmol Ther
March 2025
Team "Staphylococcal Pathogenesis", CIRI - Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of sight-threatening infections in the US. These strains pose a significant challenge in managing ocular infections, as they frequently exhibit resistance to first-line empirical antibiotics. To assess the potential of bacteriophages as innovative topical therapies for treatment of recalcitrant ocular infections, we evaluated the in vitro antimicrobial activity of a set of anti-S.
View Article and Find Full Text PDFAnn Surg Oncol
March 2025
Department of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Background: Treatment of non-small cell lung cancer (NSCLC) remains challenging; 5-year survival is as low as 24% for resectable disease. However, the outlook for stage IA NSCLC is favorable, with 5-year survival exceeding 74% and with surgery often being curative. Despite this positive prognosis, low socioeconomic status has been shown to correlate with nonstandard treatment and worse overall survival specifically in stage IA.
View Article and Find Full Text PDFRheumatol Ther
March 2025
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Introduction: Long-term treatment of psoriatic arthritis (PsA) is required to prevent progression. However, persistence with current treatments is challenging due to tolerability and acceptability issues. The objective of this study was to estimate 1-year persistence with secukinumab in patients with PsA treated with secukinumab, to compare persistence rates between secukinumab and adalimumab, to estimate usefulness rates, and to document adverse events.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!