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Moving Towards Widespread Adoption of Prostate Cancer Screening With MRI: Questions Remaining for Optimization.
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Department of Radiology, University of Minnesota Medical School.
Intranasal Delivery of Hydrophobic AC5216 Loaded Nanoemulsion into Brain To Alleviate Chronic Unpredictable Stress-Induced Depressive-like Behaviors.
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Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Basic Medicine Research and Innovation Center of Ministry of Education, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Major depressive disorder (MDD) represents a widespread mental health condition. Efficiently moving therapeutic substances across the blood-brain barrier (BBB) remains a critical obstacle in addressing depressive disorders. AC5216, identified as a translocator protein (TSPO) ligand and considered a potential treatment for major depressive disorder (MDD), faces limitations due to its subpar druggability and oral bioavailability.
View Article and Find Full Text PDFTarget detection and tracking based on single-pixel detectors enable high-speed and long-duration monitoring of fast-moving targets, showing great potential in various applications. However, traditional coding strategies based on digital micromirror devices (DMD) are significantly limited in refreshing speed and spectral response range, hindering their widespread use. Here, we propose an ultrafast and wide-spectral single-pixel tracking approach, which utilizes composite grating patterns encoded onto a spinning mask.
View Article and Find Full Text PDFToo much of a good thing: Lessons from compromised rootworm Bt maize in the US Corn Belt.
Science
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Department of Entomology, Purdue University, West Lafayette, IN, USA.
Widespread use of genetically engineered maize targeting the corn rootworm complex ( species) has raised concerns about insect resistance. Twelve years of university field trial and farm survey data from 10 US Corn Belt states indicate that maize hybrids expressing toxins derived from the bacterium (Bt maize) exhibited declining protection from rootworm feeding with increased planting while pest pressures simultaneously decreased. The analysis revealed a tendency to overplant Bt maize, leading to substantial economic losses; this was particularly striking in eastern Corn Belt states.
View Article and Find Full Text PDFThe Problem with Syngeneic Mouse Tumor Models.
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February 2025
Canaan Partners, Menlo Park, California.
The advent of syngeneic mouse tumor models provided the scientific foundation for cancer immunotherapies now in widespread use. However, in many respects, these models do not faithfully recapitulate the interactions between cancer cells and the immune systems of human patients who have solid tumors because they represent a very early stage in the immune response to the newly transplanted cancer cells compared with the relatively mature stage found in human patients at the time of treatment. The lack of translatability of syngeneic models is probably responsible for many failed clinical trials conducted at considerable expense, involving far too many patients with cancer who received no benefit.
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