The mean residual life (MRL) function plays an important role in the summary and analysis of survival data. The main advantage of this function is that it summarizes the information in units of time instead of a probability scale, which requires careful interpretation. Ranked set sampling (RSS) is a sampling technique designed for situations, where obtaining precise measurements of sample units is expensive or difficult, but ranking them without referring to their accurate values is cost-effective or easy. However, the practical application of RSS is hindered because each sample unit is required to assign a unique rank. To alleviate this difficulty, Frey developed a novel variation of RSS, called RSS-t, that records and utilizes the tie structure in the ranking process. In this paper, we propose several different nonparametric estimators for the MRL function based on RSS-t. Then, we compare the proposed estimators with their counterparts in simple random sampling (SRS) and RSS, where tie information is not utilized. We also implemented our proposed estimators on a real data set related to patient waiting times for liver transplantation, to show their applicability and efficiency in practice. Our results show that using ties information leads to an improved statistical inference for the MRL function, and therefore a smaller sample size is needed to reach a predetermined precision.
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http://dx.doi.org/10.1002/bimj.70007 | DOI Listing |
Biom J
April 2025
Department of Mathematics, University of Texas at Arlington, Arlington, Texas, USA.
The mean residual life (MRL) function plays an important role in the summary and analysis of survival data. The main advantage of this function is that it summarizes the information in units of time instead of a probability scale, which requires careful interpretation. Ranked set sampling (RSS) is a sampling technique designed for situations, where obtaining precise measurements of sample units is expensive or difficult, but ranking them without referring to their accurate values is cost-effective or easy.
View Article and Find Full Text PDFGenes Cells
March 2025
Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.
Analysis of gene trap clones (TCs) revealed the existence of regions where TCs accumulate in the absence of genes. These regions were designated as trap clone accumulation areas (TCAAs). To ascertain the physiological function of TCAAs, negative control regions devoid of genes and TCs (NC1 and NC11), two randomly selected known gene sets (G1 and G11), and a set of genes presumed to be involved in maintaining pluripotency in embryonic stem (ES) cells (GP) were generated and compared with TCAAs.
View Article and Find Full Text PDFTheor Appl Genet
March 2025
Institute of Wheat Research, Key Laboratory of Sustainable Dryland Agriculture of Shanxi Province, Shanxi Agricultural University, Linfen, China.
Several quantitative trait loci (QTL) and structural chromosome variations (SCVs) related to seedling root traits were identified using multiple methods, which provided valuable insights to assist breeding efforts in wheat. The root system of wheat affects water and fertilizer use efficiency, stress tolerance, and agronomic traits. Using association analysis and linkage mapping, QTL associated with 11 seedling-stage root traits were identified with single nucleotide polymorphisms (SNPs) and SCVs under both hydroponic nutrient solution culture experiment (NCE) and vermiculite culture experiment (VCE).
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
Department of Embryology, Bengbu Medical University, Bengbu, Anhui 233030, China; Anhui Key Laboratory of Tissue Transplantation, 2600 Donghai Avenue, Longzihu District, Bengbu, Anhui 233030, China. Electronic address:
Objective: The objective of this study was to investigate the therapeutic effects of paeoniflorin (PA) on cognitive impairment and to elucidate its potential mechanisms in MRL/lpr mice, a model of systemic lupus erythematosus-associated cognitive dysfunction.
Method: Cognitive performance and behavioral responses were assessed using a comprehensive battery of tests, including the Morris water maze, the Novel object recognition test, and the Y maze. Neuropathological changes in the hippocampal regions were visualized through Nissl, HE and Immunohistochemistry staining.
FASEB J
February 2025
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
The impaired immune regulation of bone marrow mesenchymal stem cells (BM-MSCs) disrupts T-cell homeostasis and alters the immunological environment in individuals with systemic lupus erythematosus (SLE). However, the specific molecular mechanisms underlying the defective immune functions of BM-MSCs in patients with SLE remain unclear. Here, we report that BM-MSCs derived from MRL/lpr mice exhibit a diminished proliferative capacity, elevated levels of aryl hydrocarbon receptor (AhR) and increased levels of secreted proinflammatory cytokines, including IL-1β, IL-6, and TNF-α.
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