Objective: Safety net enclosures are used in addition to (non-) pharmacological interventions in patients suffering from neuropsychiatric symptoms in dementia. However, no data on effectiveness are available.
Methods: In a prospective observational cohort study of 81 patients diagnosed with dementia, and admitted to a geriatric ward of a psychiatric hospital, available behavioral assessment scores were used to compare 45 patients who used safety net enclosures with 36 patients who never used safety net enclosures. Behavior was evaluated weekly using the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory Questionnaire (NPI-Q) at admission, start of the enclosure, and before discharge.
Results: At baseline, the intervention group had a significantly higher CMAI and NPI-Q-score. At follow-up, the intervention group showed a greater improvement in CMAI [median -13.0 (interquartile range: -27.3 to 0.05) vs 0.0 (interquartile range: -6.0 to 2.5); Mann-Whitney U = 338.5 (P = 0.005)] compared with the comparison group. Only some NPI-Q subscales showed significantly greater improvement during the intervention than in the comparison group.
Conclusions: Our observational study is the first to present effectiveness data on Neuropsychiatric symptoms in persons suffering from dementia and suggests significantly greater improvement in CMAI scores when using safety net enclosures. However, almost no significant differences were found in other outcomes.
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http://dx.doi.org/10.1097/WAD.0000000000000666 | DOI Listing |
J Gastrointest Cancer
March 2025
Department of Interventional Therapy, National Cancer Centre/National Clinical Research Centre for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Objective: To compare early recurrence patterns, safety, survival and investigate the clinical risk factors of early recurrence (ER) after liver resection or thermal ablation (TA) for patients with colorectal liver metastases (CRLM) with number ≤ 5 and largest diameter ≤ 3 cm.
Materials And Methods: This retrospective study included patients with CRLM who underwent liver resection or TA between January 2016 and December 2021 at two hospitals in China. The Kaplan-Meier method and log-rank test were used to assess recurrence-free survival (RFS) and overall survival (OS).
Alzheimer Dis Assoc Disord
March 2025
Parnassia Psychiatric Institute, Den Haag, The Netherlands.
Objective: Safety net enclosures are used in addition to (non-) pharmacological interventions in patients suffering from neuropsychiatric symptoms in dementia. However, no data on effectiveness are available.
Methods: In a prospective observational cohort study of 81 patients diagnosed with dementia, and admitted to a geriatric ward of a psychiatric hospital, available behavioral assessment scores were used to compare 45 patients who used safety net enclosures with 36 patients who never used safety net enclosures.
Nat Rev Rheumatol
March 2025
Department of Rheumatology, Saint Philibert Hospital, Lille Catholic University, Lille, France.
Gout is the most common form of inflammatory arthritis in adults worldwide. There has been a steady increase in prevalence, which varies across different geographic areas and is high in the Indigenous (First Nations) peoples of the Pacific region. Palaeo-archaeological studies demonstrate that gout was present in the Pacific region prior to European colonization, which is suggestive of genetic predisposition.
View Article and Find Full Text PDFSoc Sci Med
February 2025
Department of Behavioral, Social, & Health Education Sciences, Rollins School of Public Health, Emory University, United States.
Childhood poverty is associated with poor health in adulthood, but social policies may buffer poverty's long-term harmful effects by providing cash and in-kind resources. This study assessed the long-term health effects of welfare reform, which added work requirements, sanctions for noncompliance, lifetime limits, and family caps to welfare programming in the US in the mid-1990s. Research has found mixed evidence on the short-term health effects of welfare reform, but fewer studies have documented its impacts on health across the life course.
View Article and Find Full Text PDFCancer Treat Rev
March 2025
Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Via Rita Levi Montalcini, 4, 20072 Pieve Emanuele, Milan, Italy. Electronic address:
Treatment options for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have evolved over the past decade and have helped improve survival outcomes for patients. Most national and regional guidelines recommend first-line therapy with an immune checkpoint inhibitor (with or without chemotherapy) or a cetuximab-based regimen, by assessment of expression levels of the biomarker programmed cell death-ligand 1 (PD-L1). However, patient- and tumor-specific factors, including the patient's age, comorbidities, performance status, and tumor burden, kinetics and spread also need to be considered to optimize treatment in the first line.
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