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Utility of the ESPGHAN Biopsy Sparing Guidelines for Celiac Disease in Children.
Am J Gastroenterol
March 2025
Division of Gastroenterology, Hepatology and Nutrition, Oklahoma Children's Hospital, Department of Pediatrics, University of Oklahoma Health Science Center - College of Medicine, Oklahoma City, OK, USA.
Current practice in the management of paediatric autoimmune liver disease in Europe.
J Pediatr Gastroenterol Nutr
February 2025
Paediatric Liver, GI and Nutrition Centre, King's College Hospital NHS Trust, London, UK.
Article Synopsis
- The study examines how paediatric autoimmune liver disease (pAILD) is managed across various European medical centers, revealing significant variation in treatment approaches and drug availability.
- A survey from 36 centers indicated that most treat fewer than 50 children with pAILD, primarily using prednisolone as the first-line treatment, with azathioprine and mycophenolate as common second-line options.
- The availability of appropriate paediatric formulations for these medications is limited across Europe, highlighting the need for collaborative strategies to ensure effective and equitable treatments for affected children.
Considerations in the development of the International Multicenter Pediatric Portal Hypertension Registry.
J Pediatr Gastroenterol Nutr
January 2025
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Article Synopsis
- * The International Multicenter Pediatric Portal Hypertension Registry (IMPPHR) was created to gather data on pediatric mortality from variceal hemorrhage and strategies for prevention.
- * IMPPHR was initiated following discussions at pediatric portal hypertension meetings, began in 2020, and aims to collect data from over 700 subjects across 44 centers until data closure in 2024.
Tissue transglutaminase immunoglobulin A exceeds endomysial antibody in specificity of celiac diagnosis at ≥10 times the upper limit of normal.
J Pediatr Gastroenterol Nutr
December 2024
Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.
Objective: Serologic diagnosis using tissue transglutaminase immunoglobulin A (TTG-IgA) and endomysial antibody (EMA) is being integrated into the care of pediatric patients with positive screening for celiac disease. The purpose of this study was to assess the utility of EMA in pediatric patients being considered for serologic diagnosis.
Methods: Patients with TTG-IgA testing performed between May 1, 2022 and April 30, 2023 and with subsequent duodenal biopsy within 6 months were included.
Factors Associated With Decision to Treat or Not to Treat Helicobacter pylori Infection in Children: Data From the EuroPedHp Registry.
Helicobacter
September 2024
Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital Munich, München, Germany.
Article Synopsis
- - The study analyzed treatment decisions for H. pylori infection in children using data from the EuroPedHp Registry, focusing on various factors influencing whether or not therapy was administered, especially regarding gastrointestinal (GI) comorbidities.
- - Out of 1165 pediatric patients, those with GI comorbidities were significantly less likely to receive eradication treatment (only 57%) compared to those with no comorbidities (89%) despite having similar symptoms and conditions.
- - The findings suggest that H. pylori-infected children with GI issues had a much lower chance (75% reduced) of receiving treatment, indicating no rationale for different management approaches based on GI comorbidities in pediatric patients with confirmed infections.
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