The palladium-catalyzed dehydrogenative [4+2] annulation of 1-indanones with alkynes has been reported. In this protocol, the palladium-catalyzed desaturation of 1-indanones to indenones occurs, followed by the palladium catalyzed oxidative cyclization of indenones with alkynes, generating diverse benzo[]fluorenone derivatives in satisfactory yields and regioselectivity.
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Palladium-catalyzed oxidative cycloaddition of 1-indanones and internal aryl alkynes toward benzo[]fluorenone derivatives.
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College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
The palladium-catalyzed dehydrogenative [4+2] annulation of 1-indanones with alkynes has been reported. In this protocol, the palladium-catalyzed desaturation of 1-indanones to indenones occurs, followed by the palladium catalyzed oxidative cyclization of indenones with alkynes, generating diverse benzo[]fluorenone derivatives in satisfactory yields and regioselectivity.
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