We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet oxygen. Bioluminescence imaging-guided photodynamic therapy or O-triggered drug release are potential applications of these conjugates.
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BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc.
Chem Commun (Camb)
March 2025
Department of Chemistry, Marburg University, Marburg, Germany.
We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet oxygen. Bioluminescence imaging-guided photodynamic therapy or O-triggered drug release are potential applications of these conjugates.
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