Human immunodeficiency virus type 2 (HIV-2) is an attenuated retroviral infection characterized by specific natural susceptibility to antiretroviral drugs and acquired resistance profiles. Based on the latest knowledge of phenotypic data and clinical follow-up, HIV-2 resistance interpretation rules have been updated and implemented in a freely available resistance analysis tool.
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HIV-2EU - Supporting Standardized HIV-2 Drug Resistance Interpretation: an Update.
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Deutsche Arbeitsgemeinschaft niedergelassener Ärzte in der Versorgung HIV-Infizierter (dagnä), Berlin, Germany.
Human immunodeficiency virus type 2 (HIV-2) is an attenuated retroviral infection characterized by specific natural susceptibility to antiretroviral drugs and acquired resistance profiles. Based on the latest knowledge of phenotypic data and clinical follow-up, HIV-2 resistance interpretation rules have been updated and implemented in a freely available resistance analysis tool.
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Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, CA 92121, USA. Electronic address:
CDK4/6 inhibitors have revolutionized treatment of hormone receptor positive (HR+), HER2 non-amplified (HER2-) breast cancer. Yet, all "dual" CDK4/6 inhibitors show common dose-limiting hematologic toxicities, foremost neutropenia. This poses challenges to provide these agents at concentrations necessary to extinguish cell cycling in tumors.
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Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address:
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Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Medicine, Linyi University, Linyi 276000, P. R. China.
Superwetting surfaces have attracted considerable attention in analytical fields due to their unique ability to concentrate target analytes within evaporating droplets, characterized by a constant contact angle and a centripetal mobile contact line. While previous studies have underscored the resistance of superslippery surfaces to the coffee-ring effect, our research presents a novel strategy that dynamically introduces the coffee-ring effect on such surfaces for visual detection. By harnessing the synergistic interaction between the coffee-ring effect and the mobile contact line properties of the superslippery surface, our work leverages affinity recognition between the functionalized surface and the target analyte within the droplet to dynamically create defects for contact line pinning, thereby generating coffee rings on the superslippery surface and enabling qualitative visual detection based on their distinct patterns.
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