Worldwide, indulgence in high-risk behaviors such as substance abuse is on the rise in street children. Though substance abuse among street children has been investigated and reported in Pakistan, few studies have explored the relationship between narcotic use and its associated factors. This study was conducted to determine factors associated with narcotic use among street children in Islamabad Capital Territory. An analytical cross-sectional survey of a probability-based sample of 443 (males) street children aged 12 to 18 years, was conducted in Islamabad in March 2022. Using self-reported measures, the relationship between narcotic use and associated factors was determined using multivariate regression analysis. Out of 443 street children, with a mean age of 16.3 ± 1.6 years, 244 (55%) were between 17 and 18 years old. 119 (26.9%) worked as garbage collectors and 76 (17.2%) worked as car washers. The most common substance used was cigarettes in 285 (64.3%), naswaar in 172 (38.8%), hashish in 144 (32.5%), and alcohol in 63 (14.2%) street children. There were 164 (37%) street children who admitted having used narcotics (hashish, heroin, and bhang). On multivariate analysis, age > 16 years (OR: 2.3), sleeping on the streets (OR: 2.4), higher monthly income > Rs.18,000 (OR: 1.6), use of drugs by friends (OR: 5), and involvement in the selling of drugs (OR: 10.3) were independently associated with narcotic use. Substance abuse is a concerning trend among street children in Islamabad. When certain high-risk factors are present, these children are prone to narcotic use.
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http://dx.doi.org/10.1177/00469580251324047 | DOI Listing |
Hum Vaccin Immunother
December 2025
Department of Planned Immunization, Chaoyang District Centre for Disease Control and Prevention, Beijing, China.
Assessing knowledge of HPV and HPV vaccine and vaccine willingness among Beijing secondary school parents, and identifying decision-influencing factors. Selected via multi-stage stratified sampling, 3,081 Chaoyang secondary school students' parents participated in a June-August 2024 study. They completed a questionnaire assessing HPV knowledge, vaccine awareness, and vaccination willingness.
View Article and Find Full Text PDFJMIR Form Res
March 2025
McLean Hospital, Harvard Medical School, 115 Mill Street, South Belknap, Belmont, US.
Background: Phenylketonuria (PKU) is a rare, hereditary disease that causes disruption in phenylalanine (Phe) metabolism. Despite early intervention, individuals with PKU may have difficulty in several different cognitive domains, including verbal fluency, processing speed, and executive functioning.
Objective: The overarching goal of the Evaluating Fluctuations in Cognitive and Speech Characteristics in Phenylketonuria study (CSP Study) is to characterize the relationships among cognition, speech, mood, and blood-based biomarkers (Phe, Tyr) in individuals with early treated PKU.
J Community Genet
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North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Genomic medicine (GM) was mainstreamed across the National Health Service (NHS) in England in 2018. Non-genetics healthcare professionals can now incorporate genomic testing including whole genome sequencing (WGS) into their clinical practice. This study was conducted to evaluate the preparedness of community paediatricians (CPs) for GM.
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Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Kangfu Qian Street 7, Zhengzhou, 450052, China.
Neuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunction, arrest of oligodendrocyte maturation, and long-term neurological damage. As a potential therapeutic strategy, mesenchymal stem cells (MSCs) exhibit significant immunomodulatory and regenerative potential. Recent studies suggest that the primary mechanism of MSC action is their paracrine effects, particularly mediated by extracellular vesicles, with MSC-derived exosomes (MSC-Exos) being the key mediators.
View Article and Find Full Text PDFWorldwide, indulgence in high-risk behaviors such as substance abuse is on the rise in street children. Though substance abuse among street children has been investigated and reported in Pakistan, few studies have explored the relationship between narcotic use and its associated factors. This study was conducted to determine factors associated with narcotic use among street children in Islamabad Capital Territory.
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