The plenary session on "End organ damage and repair" at the 21st International Vasculitis Workshop Congress featured two lectures and three studies addressing the pathogenesis, diagnosis, and management of fibrosis in vasculitis. The studies presented at the session demonstrate the importance of cellular interplay in driving inflammation and fibrosis, like the B cell-fibroblast interactions in the aorta of giant cell arteritis patients and the potential fibrotic role of specific infiltrating macrophage subtypes in ANCA-associated glomerulonephritis. Moreover, organ damage, such as the presence of interstitial lung disease in ANCA-associated vasculitis, may impact on long-term outcome, and need a personalized treatment approach.
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Highlights from the plenary session: eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome.
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Nephrology and Dialysis Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA) both present with hypereosinophilia and organ damage induced by eosinophils. EGPA is also characterized by vasculitis and is associated with ANCA. Yet, discriminating HES from EGPA may be difficult in clinical practice as biomarkers to reliably differentiate between HES and EGPA are still lacking.
View Article and Find Full Text PDFHighlights from the plenary session: cellular and molecular mechanisms of disease (I).
Rheumatology (Oxford)
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Vasculitis Expertise Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
In this plenary session of the Vasculitis Workshop 2024, pioneering translational research on autoimmune vasculitis, particularly ANCA-associated vasculitis (AAV), was presented, highlighting advancements in our understanding of disease mechanisms and promising therapeutic prospects. Advances in elucidating molecular pathways, such as IL-17 and IFN-I, pave the way for specific treatments. Preclinical studies have revealed the gut microbiome's role in the pathogenesis of MPO-AAV and demonstrate the therapeutic potential of dietary interventions.
View Article and Find Full Text PDFHighlights from the plenary session: clinically relevant outcomes.
Rheumatology (Oxford)
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Vasculitis Unit of Vienna, Vienna, Austria.
The plenary session on clinically relevant outcomes in systemic vasculitis emphasized the significance of monitoring creatinine, haematuria and proteinuria for predicting renal outcomes, recovery of kidney function in severe ANCA glomerulonephritis and outcomes post-kidney transplantation in anti-glomerular basement membrane disease. These findings have the potential to enhance clinical practice by refining prognostication and treatment strategies. Future research gaps include exploring the predictive role of proteinuria and understanding the impact of different clinical phenotypes on disease outcomes in Takayasu arteritis.
View Article and Find Full Text PDFHighlights from the plenary session: advances in treatment (I).
Rheumatology (Oxford)
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Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology, ERN-RITA Reference Center, Medius Kliniken-Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim-unter-Teck, Germany.
Highlights from the plenary session: end-organ damage and repair.
Rheumatology (Oxford)
March 2025
Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
The plenary session on "End organ damage and repair" at the 21st International Vasculitis Workshop Congress featured two lectures and three studies addressing the pathogenesis, diagnosis, and management of fibrosis in vasculitis. The studies presented at the session demonstrate the importance of cellular interplay in driving inflammation and fibrosis, like the B cell-fibroblast interactions in the aorta of giant cell arteritis patients and the potential fibrotic role of specific infiltrating macrophage subtypes in ANCA-associated glomerulonephritis. Moreover, organ damage, such as the presence of interstitial lung disease in ANCA-associated vasculitis, may impact on long-term outcome, and need a personalized treatment approach.
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