The breakout session "Imaging in Disease Assessment" featured six abstracts on imaging advancements for vasculitis. Disease extent on cranial MRI and its association with visual complications in giant cell arteritis (GCA) was evaluated, introducing the Propensity for Enhancement for GCA (P EG) score to assess inflammation. Predictors of remission and relapse in chronic periaortitis were analyzed, suggesting the potential for tailored treatment approaches. A novel radiomic model using CT chest scans accurately predicted relapses in ANCA-associated vasculitis. FDG-PET for monitoring GCA in patients on tocilizumab demonstrated limited predictive value. Comparative assessments of Takayasu arteritis using the Takayasu Arteritis Disease Activity Index (TAIDAI) highlighted the need for standardized evaluations. Finally, a protocolized ultrasonography pathway for diagnosing large vessel vasculitis showed promising results, suggesting a combined ultrasound and second test approach, guided by CRP levels, as a gold standard. The session emphasized integrating imaging biomarkers with clinical assessments to improve disease management.
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http://dx.doi.org/10.1093/rheumatology/keae408 | DOI Listing |
Rheumatology (Oxford)
March 2025
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rheumatology (Oxford)
March 2025
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Rheumatology (Oxford)
March 2025
Vasculitis and Lupus Clinic, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
This session presented emerging realworld evidence on novel glucocorticoid (GC) sparing therapies for ANCA-associated vasculitis (AAV). It covered the first-in-class oral C5a receptor antagonist avacopan for severe granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), and antiinterleukin-5 therapies in the management of eosinophilic granulomatosis with polyangiitis (EGPA). Avacopan was approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of AAV in 2021, following the phase 3 ADVOCAT E trial comparing oral avacopan to an oral GC taper for GPA and MPA.
View Article and Find Full Text PDFRheumatology (Oxford)
March 2025
Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
The session on other forms of vasculitis included a masterful review on IgG4-related disease (IgG4-RD) following which two research studies evaluating therapeutic agents and one study on histopathologic findings of IgG4-RD were presented. Peyronel F., et al.
View Article and Find Full Text PDFRheumatology (Oxford)
March 2025
Department of Nephrology, Fundacio Puigvert and Autónoma de Barcelona University, Barcelona, Spain.
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