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Ochronotic arthropathy: skeletal manifestations and orthopaedic treatment.
EFORT Open Rev
February 2025
Alkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage. It is characterized by a triad of homogentisic aciduria, bluish-black discoloration of connective tissues (ochronosis) and arthropathy of the spine and large weight-bearing joints. Several clinical manifestations were described including coronary and valvular calcification, aortic stenosis, limited chest expansion, and renal, urethral and prostate calculi as well as ocular and cutaneous pigmentation.
View Article and Find Full Text PDFCutaneous pigmentation and sensory ataxia in vitamin B12 deficiency.
J R Coll Physicians Edinb
March 2025
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India.
Evaluation of the Efficacy of a Serum Containing Niacinamide, Tranexamic Acid, Vitamin C, and Hydroxy Acid Compared to 4% Hydroquinone in the Management of Melasma.
J Cosmet Dermatol
March 2025
Department of Dermatology, CHU Nice, Université Côte d'Azur, Nice, France.
Introduction: Melasma is a common skin condition that remains challenging to treat. Hydroquinone at 4% (HQ4%) is a frequently prescribed depigmenting compound that has been associated with potential side effects.
Objective: This study assessed the benefit in melasma of an anti-hyperpigmentation serum (Serum B3 containing 5% niacinamide, 1% tranexamic acid, 0.
Cutaneous metallosis following ceramic insert fracture in total hip arthroplasty: a case report and revision with ceramic-on-ceramic bearing couple.
SICOT J
March 2025
Department of Orthopedic Surgery, Groupe Hospitalier Diaconesses Croix Saint-Simon, 125 rue d'Avron, 75020 Paris, France.
Ceramic fractures in total hip arthroplasty (THA) are rare complications that pose significant challenges for revision surgery. This case report describes a 68-year-old male who experienced a spontaneous alumina (ceramic) insert and head fracture four years after the initial THA. The first revision with cobalt-chrome and polyethylene components led to severe metallosis, including subcutaneous tissue discoloration.
View Article and Find Full Text PDFObjective Assessment and Quantification of Skin Color and Melanin in Neonates and Infants: A State-Of-The-Art Review.
Pediatr Dermatol
March 2025
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Neonatal skin color, especially melanin assessment, remains an underexplored topic in neonatology and dermatology literature. Growing concerns about racial bias in pulse oximeters in adults highlight the need for objective assessment of skin color to investigate if skin pigmentation contributes to the inaccuracy. While skin color scales and cutaneous colorimetric devices have been utilized in adult dermatology for various applications, their use and effectiveness in neonates and infants are not well understood.
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