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| http://dx.doi.org/10.1183/23120541.00816-2024 | DOI Listing |
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Delayed airway epithelial repair is correlated with airway obstruction in young adults born very preterm.
ERJ Open Res
March 2025
Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, Australia.
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View Article and Find Full Text PDFModulation of the Epithelial-mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury.
Respir Res
March 2025
Department of Thoracic Surgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, People's Republic of China.
Background: Epithelial-mesenchymal transition (EMT) is regarded as a key process in repair of airway epithelium after injury. Forkhead Box C2 (FOXC2) is a transcription factor involved in EMT process, whether it is involved in repair of bronchial epithelium remains unknown.
Methods: C57BL/6 mice were subjected to intraperitoneal injection with naphthalene (NAPH; 200 mg/kg) to induce airway injury model.
Acupuncture inhibits epithelial mesenchymal transition in allergic asthma rats by activating the PI3K/AKT pathway through DEK activation.
Zhen Ci Yan Jiu
February 2025
Shanxi Acupuncture Hospital, Taiyuan 030006.
Objectives: To observe the effect of acupuncture at "Dazhui" (GV14) and "Shenzhu" (GV12) on DEK/phosphorylated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and epithelial-mesenchymal transition related factors in rats with allergic asthma (AA), so as to explore its potential mechanism in the treatment of AA.
Methods: Sixty SD rats were randomly divided into normal, model, acupuncture, dexamethasone (DEX) and sham-acupuncture groups, with 12 rats in each group. The AA model was made by intraperitoneal injection of mixture solution of ovalbumin and aluminium hydroxide gel (on day 1 and 7) and followed by inhalation of atomized 1% ovalbumin (30 min, from day 15, once daily for 14 days).
Developmental air pollution exposure augments airway hyperreactivity, alters transcriptome, and DNA methylation in female adult progeny.
Commun Biol
March 2025
School of Life Sciences, University of Technology Sydney, Sydney, Australia.
Maternal exposure to particulate air pollution increases the incidence and severity of asthma in offspring, yet the mechanisms for this are unclear. Known susceptibility loci are a minor component of this effect. We interrogate a mouse allergic airway disease model to assess epigenetic associations between maternal air pollution exposure and asthma responses in offspring.
View Article and Find Full Text PDFPrehospital Trauma Compendium: Management of Injured Pregnant Patients- A Position Statement and Resource Document of NAEMSP.
Prehosp Emerg Care
March 2025
Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
The assessment and management of critically injured pregnant trauma patients represents a high-risk, low-frequency event. One in every 12 pregnant patients experience physical trauma during their pregnancy, but only 0.1% experience major trauma with an injury severity score (ISS) greater than fifteen.
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