We report a rare clinical presentation of a 54-year-old male diagnosed with infective endocarditis caused by , a nutritionally variant streptococcus (NVS) characterized by unique growth requirements and high pathogenic potential. The patient presented with prolonged fever and residual hemiparesis following an ischemic stroke. Blood culture confirmed , and imaging identified vegetations on a bicuspid aortic valve. Despite prompt antibiotic therapy, the course was complicated by acute intraventricular hemorrhage (IVH) and hydrocephalus, culminating in a fatal outcome. This report underscores the pathogenic challenges posed by , highlights its catastrophic complications, and reviews its presentation and management in the context of existing literature and emphasizing the importance of prompt diagnosis, tailored antibiotic therapy, and vigilant monitoring.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892434PMC
http://dx.doi.org/10.53854/liim-3301-14DOI Listing

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