The COVID-19 pandemic highlights the global threat posed by emerging viruses, emphasizing the critical need for effective strategies to combat pathogen transmission. Moreover, alongside emerging viruses, the increasing threat of antimicrobial resistance further reinforces the need to develop novel methods for infection control. Anti-pathogenic coatings on textiles offer a promising solution; in this study, three electroless copper-plated fabrics are evaluated for their antipathogenic properties following International Standards Organisation (ISO) standards. Prior to electroless plating, materials are activated either by immersion in a Pd catalyst solution (material A) or by ink-jet printing Cu/Ag catalyst along the weft (material B) or warp thread (material C). This study demonstrates that activation method influences the materials antipathogenic performance, with all materials achieving complete bactericidal/fungicidal neutralization within 30 min of incubation. Material B exhibits up to 4-log virucidal effects within 1 h against viruses such as coronavirus (OC43, 229E), Influenza A (H1N1), and Rotavirus A. Furthermore, biocompatibility testing indicates that material B exhibited low in vitro cytotoxicity. Textile B demonstrates strong antibacterial results even after one year of accelerated aging with no significant difference ( = 0.74) in efficiency against MRSA, highlighting promising applications for infection control in clinical settings reducing pathogen transmission, nosocomial infections and the associated economic burden.
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http://dx.doi.org/10.1002/gch2.202400346 | DOI Listing |
Pediatr Infect Dis J
March 2025
From the Department of Emergency and Transport Medicine, National Center for Child Health and Development, Tokyo, Japan.
Febrile infants 8-60 days of age underwent multiplex polymerase chain reaction (mPCR) testing in the emergency department. The virus-positive rate was 61.3%, with serious bacterial infections (SBIs) at 12.
View Article and Find Full Text PDFAm J Public Health
April 2025
Kristen M. Brown, Brigette Courtot, Zara Porter, and Sofia Hinojosa are with the Health Policy Center, Urban Institute, Washington, DC.
The Centers for Disease Control and Prevention's Partnering for Vaccine Equity program was developed during the COVID-19 public health emergency to fund more than 500 community-based organizations working to improve vaccine equity. Organizations were supported by a virtual learning community where members received tailored learning content, peer-to-peer learning opportunities, and resources that facilitated deployment of vaccine-related programming during a dynamic pandemic. Process evaluation metrics indicate successful implementation of the learning community.
View Article and Find Full Text PDFJ Immunol
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
As one of the earliest identified susceptible animals for the SARS-CoV-2, cats are also the vulnerable hosts for feline coronaviruses, ie feline enteric coronavirus (FECV). Here, to understand the cross-presentation of coronavirus-derived peptides by cat major histocompatibility complex molecule feline leucocyte antigen (FLA) class I, unpredictable natural peptide motifs presented by FLA-K*00701 and FLA-E*00301 were identified through peptide elution and further confirmed by the structural determination of the 2 FLA class I molecules. Based on these precise motifs of FLA class I peptides, the atlas of cross-presenting peptides from different coronaviruses in cats were sketched with 3 hotspots in C-terminal half of ORF1ab protein.
View Article and Find Full Text PDFJ Immunol
February 2025
Department of Emergency Medicine, Second Affiliated Hospital, Department of Epidemiology and Biostatistics, School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Immune memory is crucial for preventing hepatitis E virus (HEV) infection. Our study aims to investigate immunological memory characteristics and differences between vaccination and natural HEV infection, taking into account that both can induce immune memory. We recruited 60 HEV-infected patients, 58 contingency HEV-vaccinated individuals and 4 controls from an outbreak of hepatitis E in a nursing home between June and August 2023.
View Article and Find Full Text PDFCrit Care Sci
March 2025
Division of Critical Care Medicine, Department of Pediatrics, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - São Paulo (SP), Brazil.
Apnea is a major complication of acute respiratory tract infection in young infants and may lead to the need for ventilatory support. Caffeine is methylxanthine, which is considered the mainstay of pharmacologic treatment for apnea of prematurity. On the basis of neonatal guidelines, caffeine has been used as a respiratory stimulant for the treatment of acute respiratory tract infection-related apnea, despite low evidence of its ability to improve clinical outcomes.
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