Description This article discusses how monthly extended-release buprenorphine can be used to improve the treatment of opioid use disorder (OUD). In particular, the use of monthly extended-release buprenorphine holds promise for patients who have recently been released from jail or prison and are battling OUD, those who are unstable and continue to use opioids illicitly, patients who are experiencing homelessness while also struggling with OUD, and those who are stable and want to be weaned off buprenorphine.
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http://dx.doi.org/10.36518/2689-0216.1680 | DOI Listing |
HCA Healthc J Med
February 2025
Mountain Area Health Education Center, Asheville, North Carolina.
Description This article discusses how monthly extended-release buprenorphine can be used to improve the treatment of opioid use disorder (OUD). In particular, the use of monthly extended-release buprenorphine holds promise for patients who have recently been released from jail or prison and are battling OUD, those who are unstable and continue to use opioids illicitly, patients who are experiencing homelessness while also struggling with OUD, and those who are stable and want to be weaned off buprenorphine.
View Article and Find Full Text PDFDrug Alcohol Depend
February 2025
Opioid Policy Research Collaborative, Brandeis University, Waltham, MA, USA.
Introduction: Incarcerated individuals with opioid use disorder experience high rates of opioid-related mortality upon release. Buprenorphine and methadone are effective at reducing mortality rates in this population, but evidence for extended-release naltrexone is mixed. We evaluated a comprehensive jail-based program in Massachusetts (MATADOR 2.
View Article and Find Full Text PDFInt J Drug Policy
February 2025
Yale School of Medicine, Section of Infectious Diseases, New Haven, CT, United States; APT Foundation, New Haven, CT, United States; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, United States; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, United States.
Background And Aims: Maintenance on medications for opioid use disorder, particularly buprenorphine, is critical for reducing overdose risk and improving health outcomes in the United States. This study evaluates retention and dropout probabilities between sublingual buprenorphine (SL-BUP) and extended-release buprenorphine (XR-BUP) among commercially-insured individuals with opioid use disorder (OUD).
Design And Setting: A retrospective cohort study using Meretive™ Markeskan® claims data from 2019 to 2020.
Drug Alcohol Depend
February 2025
Massachusetts General Hospital, 100 Cambridge Street, 16th Floor, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Boston Health Care for the Homeless Program, 780 Albany Street, Boston, MA 02118, USA.
Introduction: People experiencing homelessness face high rates of opioid-related mortality. Buprenorphine is a medication that reduces opioid-related mortality, but adherence to this medication among people experiencing homelessness is not well-documented. This study assessed buprenorphine adherence and identified factors associated with it in this high-risk population.
View Article and Find Full Text PDFAm J Vet Res
February 2025
Department of Molecular and Cellular Endocrinology, City of Hope Beckman Research Institute, Duarte, CA.
Objective: To determine the pharmacokinetics of extended-release buprenorphine (XRB) in adult swine. We hypothesized that after a single SC administration of XRB in swine, buprenorphine plasma concentrations would be at or above the therapeutic threshold of 0.1 ng/mL and would not result in major injection site reactions.
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