Tropical medicine, initially associated with colonial medicine and exotic pathology, focused on infectious diseases of warm regions and on environmental and socioeconomic imbalances. Global upheavals such as globalization, urbanization and climate change have broadened the scope of diseases, with the emergence of tropical pathologies in temperate regions and an increase in non-communicable diseases (traumatic, metabolic, psychiatric, etc.) in southern countries. accompanies this paradigm shift by integrating noncommunicable diseases and contextualizing the local conditions in which pathologies occur, are diagnosed and treated. It favors analyses based on local specificities, including cultural, socioeconomic and environmental aspects, as well as health system constraints. therefore insists on contextualization in submitted articles, especially for original studies and clinical cases, emphasizing the impact of local conditions, diagnostic and therapeutic barriers, and the consideration of traditional medicines. It invites authors to demonstrate the relevance and novelty of their observations, while respecting the formal recommendations for publication.
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http://dx.doi.org/10.48327/mtsi.v4i4.2024.618 | DOI Listing |
ACS Sens
March 2025
Centre for Innovative Materials for Health, School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
Herein, a novel and simple electrospray (ES) printing technique was developed for the fabrication of ultrathin graphene layers with precisely controlled nanometer-scale thickness, where graphene oxide (GO) was electrosprayed on wafers and subsequently chemically reduced into reduced GO (rGO). Utilizing that technique, we prepared ultrathin rGO in-plane graphene field-effect transistor (GFET)-based biosensors coupled with a portable prototype measuring system for point-of-care detection of pathogens. We illustrate the use of such prepared GFETs to detect COVID-19, using the SARS-CoV-2 nucleocapsid protein antigen (N-protein) and genomic viral RNA as detection targets.
View Article and Find Full Text PDFEur J Cardiothorac Surg
March 2025
Department of Pediatrics, University of Toyama, Graduate School of Medicine, Toyama, Japan.
Objectives: Although there has been rapid development in the field of three-dimensional morphological analyses of congenital heart disease, with the three-dimensional volume-rendered images providing visualization of the external vascular anatomy, the precise reproduction of "Swiss-cheese" ventricular septum is not well established. We created three-dimensional printed models and computer graphics based on multi-slice computed tomography of patients with complex multiple ventricular septal defects for surgical decision planning of this difficult cardiac defect.
Methods: Seven patients with complex multiple ventricular septal defects were evaluated preoperatively using three-dimensional printed models and computer graphics to plan therapeutic interventions.
Ann Intern Med
March 2025
The Division of Cardiology, University of Cape Town, and the SAMRC EMU on the Interaction of Cardiovascular and Infectious Diseases, Cape Town, South Africa.
Sci Adv
March 2025
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored.
View Article and Find Full Text PDFAnnu Rev Chem Biomol Eng
March 2025
1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA; email:
Respiratory conditions represent a significant global healthcare burden impacting hundreds of millions worldwide and necessitating new treatment paradigms. Pulmonary immune engineering using synthetic nanoparticle (NP) platforms can reprogram immune responses for therapeutically beneficial or protective responses directly within the lung tissue. However, effectively localizing these game-changing approaches to the lung remains a significant challenge due to the lung's natural defense.
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